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Composites and Structures for Regenerative Engineering

机译：再生工程用复合材料和结构

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摘要

Regenerative engineering was conceptualized by bridging the lessons learned in developmental biology and stem cell science with biomaterial constructs and engineering principles to ultimately generate de novo tissue. We seek to incorporate our understanding of natural tissue development to design tissue-inducing biomaterials, structures and composites than can stimulate the regeneration of complex tissues, organs, and organ systems through location-specific topographies and physico-chemical cues incorporated into a continuous phase. This combination of classical top-down tissue engineering approach with bottom-up strategies used in regenerative biology represents a new multidisciplinary paradigm. Advanced surface topographies and material scales are used to control cell fate and the consequent regenerative capacity. Musculoskeletal tissues are critical to the normal functioning of an individual and following damage or degeneration they show extremely limited endogenous regenerative capacity. The increasing demand for biologically compatible donor tissue and organ transplants far outstrips the availability leading to an acute shortage. We have developed several biomimetic structures using various biomaterial platforms to combine optimal mechanical properties, porosity, bioactivity, and functionality to effect repair and regeneration of hard tissues such as bone, and soft tissues such as ligament and tendon. Starting with simple structures, we have developed composite and multi-scale systems that very closely mimic the native tissue architecture and material composition. Ultimately, we aim to modulate the regenerative potential, including proliferation, phenotype maturation, matrix production, and apoptosis through cell-scaffold and host -scaffold interactions developing complex tissues and organ systems.
机译：通过将在发育生物学和干细胞科学中获得的经验与生物材料构造和工程原理相结合，从而最终生成新的组织，从而对再生工程进行了概念化。我们力求结合对自然组织发育的理解，来设计诱导组织的生物材料，结构和复合材料，从而通过结合到特定阶段的特定位置地形图和理化线索来刺激复杂组织，器官和器官系统的再生。经典的自上而下的组织工程方法与自下而上的策略在再生生物学中的结合代表了一种新的多学科范式。先进的表面形貌和材料比例被用于控制细胞命运和随之而来的再生能力。肌肉骨骼组织对于个体的正常功能至关重要，并且在受损或变性后，它们显示出极为有限的内源性再生能力。对生物相容性供体组织和器官移植的需求不断增长，远远超过了可用性，导致严重短缺。我们已经使用各种生物材料平台开发了几种仿生结构，以结合最佳的机械性能，孔隙率，生物活性和功能性，以实现对硬组织（如骨头）和软组织（如韧带和腱）的修复和再生。从简单的结构开始，我们已经开发了非常类似于天然组织结构和材料组成的复合和多尺度系统。最终，我们旨在通过形成复杂组织和器官系统的细胞支架和宿主支架相互作用来调节再生潜能，包括增殖，表型成熟，基质产生和凋亡。

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  • 会议地点 Boston MA(US)
  • 作者

    Cato T. Laurencin; Roshan James;

  • 作者单位

    Institute for Regenerative Engineering The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A,The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A,Connecticut Institute for Clinical and Translational Science The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A ,Department of Orthopaedic Surgery The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A;

    Institute for Regenerative Engineering The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A,The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A,Department of Orthopaedic Surgery The University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030, U.S.A;

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