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Novel and Unique Matrix Design for Osteochondral Tissue Engineering

机译：骨软骨组织工程的新颖独特矩阵设计

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摘要

Osteochondral (OC) tissue is comprised of articular cartilage, the subchondral bone and the central cartilage-bone interface. To facilitate proper regeneration, an equally complex and multi-phasic matrix must be used. Although mono-phasic and bi-phasic matrices were previously applied, they failed to establish the OC interface upon regeneration. In this study, we designed and developed a novel matrix with increasing pore volume from one end to other, along the matrix length. For this matrix polylactide-co-glycolide (PLGA) 85:15 microspheres were combined with a water-soluble porogen in a layer-by-layer fashion and thermally sintered. The resulting matrix was then porogen-leached to form a gradiently-porous structured matrix. The formation of this gradient pore structure was established using Micro-Computed Tomography (uCT) scanning. A biodegradable hydrogel was infiltrated into the structure to form a unique OC matrix where the microsphere and hydrogel phases co-exist with opposing gradients. When the individual phases are associated with osteogenic and chondrogenic growth factors, the structure-induced factor delivery might provide the spatially controlled factor delivery necessary to regenerate osteochondral tissue structure. Overall, we designed a gradient matrix system that is expected to support osteochondral tissue engineering while forming a seamless interface between the cartilage and the bone matrix.
机译：骨软骨组织（OC）由关节软骨，软骨下骨和中央软骨-骨界面组成。为了促进适当的再生，必须使用同等复杂和多相的矩阵。尽管以前使用了单相和双相矩阵，但它们在再生时无法建立OC接口。在这项研究中，我们设计并开发了一种新型基质，该基质沿着基质的长度从一端到另一端的孔体积不断增加。对于该基质，将丙交酯-共-乙交酯（PLGA）85:15微球与水溶性致孔剂逐层结合并进行热烧结。然后将所得的基质进行成孔剂浸提以形成梯度多孔的结构化基质。使用微计算机断层扫描（uCT）扫描确定了该梯度孔结构的形成。将可生物降解的水凝胶渗透到结构中以形成独特的OC基质，其中微球和水凝胶相以相反的梯度共存。当各个阶段与成骨和软骨形成生长因子相关时，结构诱导因子传递可能提供再生骨软骨组织结构所必需的空间控制因子传递。总体而言，我们设计了一种梯度矩阵系统，该系统有望支持骨软骨组织工程，同时在软骨和骨矩阵之间形成无缝的界面。

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  • 会议地点 Boston MA(US)
  • 作者

    Deborah L. Dorcemus; Syam P. Nukavarapu;

  • 作者单位

    Institute for Regenerative Engineering, University of Connecticut Health Center Farmington, CT 06030, U.S.A,Biomedical Eng. University of Connecticut Storrs, CT 06269, USA;

    Institute for Regenerative Engineering, University of Connecticut Health Center Farmington, CT 06030, U.S.A,Biomedical Eng. University of Connecticut Storrs, CT 06269, USA,Materials Science Eng. University of Connecticut Storrs, CT 06269, USA,Department of Orthopedic Surgery University of Connecticut Health Center Farmington, CT 06030, U.S.A;

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