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首页> 外文会议>American Association of Textile Chemists and Colorists (AATCC) 1999 International Conference amp; Exhibition Oct 12-15, 1999, Charlotte, N.C. >DYEING POLYURETHANES WITH ANTIBIOTICS: PROLONGED INFECTION RESISTANCE WITHOUT EXOGENOUS BINDERS
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DYEING POLYURETHANES WITH ANTIBIOTICS: PROLONGED INFECTION RESISTANCE WITHOUT EXOGENOUS BINDERS

机译：含抗菌剂的聚氨酯染色：无外源粘合剂的持久抗感染能力

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摘要

Direct polymer/antibiotic interaction is a promising means of providing infection-resistant polyu-rethane. What would be a poor dye (low exhaustion and easy removal from the fiber) represents a good candidate for a material with sustained antibiotic release. Such methods and materials offer several advantages over previous methods for binding antibiotics to biomedical materials: 1) no modification of antibiotic is needed to bind with polyurethane, so it maintains full antimicrobial activity; 2) no exogenous materials are introduced, thus avoiding complications of toxicity, bio-compatibility, and mutagenecity of this infection-resistant material The use of methods derived from the textile industry provides the tools with which to optimize the uptake of antibiotic, and dyeing theory provides both an explanation of the interaction, and a measure of the attraction. This in turn suggests a potential predictor of release rates and times without conducting extensive biological testing.
机译：直接的聚合物/抗生素相互作用是提供抗感染聚氨酯的一种有前途的手段。较差的染料（低耗竭且容易从纤维上去除）代表了具有持续释放抗生素的材料的良好选择。这样的方法和材料相对于以前的将抗生素与生物医学材料结合的方法具有几个优点：1）不需要修饰抗生素即可与聚氨酯结合，因此可以保持完全的抗菌活性； 2）不引入外源材料，从而避免了这种抗感染材料的毒性，生物相容性和致突变性的复杂性纺织工业方法的使用提供了优化抗生素吸收和染色原理的工具提供相互作用的解释和吸引力的度量。这反过来暗示了在不进行大量生物学测试的情况下，释放速率和释放时间的潜在预测指标。

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