Applications of Radioanalytical Chemistry to Alzheimer's Disease

机译：放射分析化学在阿尔茨海默氏病中的应用

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Two examples of the use of radioanalytical methods to probe key questions about the pathogenesis of Alzheimer's disease (AD) are presented. In the first, micro-beam proton-induced X-ray emission analysis was used to investigate imbalances of Zn in senile plaques (SP) and neurofibrillary tangles (NFT) in AD in light of observations that this metal can accelerate aggregation of amyloid beta peptide in vitro. In the second, accelerator mass spectrometry and the ~(14)C bomb pulse were used to determine the average "age" of NFT and SP in the AD brain to help define the time course and defining factors involved in the formation of these pathological features.

机译：给出了两个使用放射分析方法来探究有关阿尔茨海默氏病（AD）发病机理的关键问题的例子。首先，微束质子诱导的X射线发射分析用于研究AD中老年斑（SP）和神经原纤维缠结（NFT）中锌的失衡，原因是这种金属可以促进淀粉样β肽的聚集体外。第二，使用加速器质谱和〜（14）C炸弹脉冲来确定AD大脑中NFT和SP的平均“年龄”，以帮助定义时间过程并确定与这些病理特征形成有关的因素。

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《American Chemical Society(ACS) National Meeting; 20020408-20020410; Orlando,FL; US》|2002年|P.298-306|共9页
会议地点 Orlando FL(US);Orlando FL(US)
作者
J. D. Robertson; M. A. Lovell;
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Department of Chemistry and Missouri University Research Reactor, University of Missouri, Columbia, MO 65211;

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原文格式 PDF
正文语种 eng
中图分类核转变化学;
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Applications of Radioanalytical Chemistry to Alzheimer's Disease

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