首页> 外文会议>American Chemical Society, Meeting, 2000, San Francisco, Calif >AlphaScreen~(TM): A Highly Sensitive, Nonradioactive and Homogeneous Assay Platform for Drug Discovery High Throughput Screening, Genomics, and Life Science Research Applications in Miniaturized Format

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AlphaScreen~(TM): A Highly Sensitive, Nonradioactive and Homogeneous Assay Platform for Drug Discovery High Throughput Screening, Genomics, and Life Science Research Applications in Miniaturized Format

机译：AlphaScreen〜（TM）：一种用于药物发现的高灵敏度，非放射性和均质的测定平台，以小尺寸形式进行高通量筛选，基因组学和生命科学研究

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AlphaScreen~(TM) (Amplified Luminescent Proximity Homogeneous Assay) is a novel assay platform suitable for a broad range of applications in high throughput screening (HTS), genomics, and life science research and development. This proximity based, non-radioactive assay technology is highly sensitive and robust. Assays have been performed in 96/384/1536 well plates using the AlphaQuest~(TM) Analyzer. Miniaturization does not require increasing assay component concentration. Applications include enzyme assays, protein-protein and protein-DNA interactions, a functional cAMP assay, DNA and RNA quantitation, and SNP analysis.

机译：AlphaScreenTM（扩增发光邻近均相测定）是一种新颖的测定平台，适用于高通量筛选（HTS），基因组学和生命科学研究的广泛应用。这种基于邻近度的非放射性分析技术高度灵敏且坚固。已经使用AlphaQuestTM分析仪在96/384/1536孔板中进行了测定。小型化不需要增加测定成分的浓度。应用包括酶法测定，蛋白质-蛋白质和蛋白质-DNA相互作用，功能性cAMP测定，DNA和RNA定量以及SNP分析。

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《American Chemical Society, Meeting, 2000, San Francisco, Calif》|2000年|p.45-56|共14页
会议地点 San Francisco CA(US)
作者
Changjin Wang; Roger Bosse; Chantal Illy; Lucille Beaudet; Philippe Roby; Marcia Budarf; Kenneth Neumann; Juerg Duebendorfer; Donald Jones; Daniel Chelsky;
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作者单位

Packard BioScience Company, 800 Research Parkway, Meriden, CT 06450;

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原文格式 PDF
正文语种 eng
中图分类自动化技术、计算机技术;
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专利

1. Development of homogeneous 384-well high-throughput screening assays for A beta 1-40 and A beta 1-42 using AlphaScreen (TM) technology [J] . Szekeres PG, Leong K, Day TA, Journal of biomolecular screening: The official journal of the Society for Biomolecular Screening . 2008,第2期

机译：使用AlphaScreen（TM）技术开发用于A beta 1-40和A beta 1-42的均相384孔高通量筛选测定
2. Membranes in life science applications: improving throughput in genomics, proteomics, and drug discovery [J] . KENNETH W. LUDWIG American Biotechnology Laboratory . 2003,第8期

机译：生命科学应用中的膜：提高基因组学，蛋白质组学和药物发现的通量
3. Miniaturization and validation of a high-throughput serine kinase assay using the AlphaScreen platform [J] . von Leoprechting A, Kumpf R, Menzel S, Journal of biomolecular screening: The official journal of the Society for Biomolecular Screening . 2004,第8期

机译：使用AlphaScreen平台进行高通量丝氨酸激酶测定的小型化和验证
4. Data Mining: A Unifying Approach for Drug Discovery Integrating genomics, combinatorial chemistry, high throughput screening, and DNA microarrays for drug discovery [C] . Leming Shi Biochip technologies . 2000

机译：数据挖掘：药物发现的统一方法整合基因组学，组合化学，高通量筛选和DNA微阵列进行药物发现
5. High throughput assays for drug discovery and clinical applications. [D] . Prudom, Catherine Elizabeth. 2007

机译：用于药物发现和临床应用的高通量检测。
6. Development of a High-Throughput Screening–Compatible Assay for the Discovery of Inhibitors of the AF4-AF9 Interaction Using AlphaScreen Technology [O] . Venita Gresham Watson, Katherine M. Drake, Yu Peng, -1

机译：高通量筛选兼容的检测方法的开发用于使用AlphaScreen技术发现AF4-AF9相互作用的抑制剂
7. Development of Homogeneous 384-Well High-Throughput Screening Assays for Aβ1-40 and Aβ1-42 Using AlphaScreen™ Technology [O] . Philip G. Szekeres, Kaitlin Leong, Theresa A. Day, 2008

机译：使用AlphaScreen TM技术的Aβ1-40和Aβ1-42的均匀384孔高通量筛选测定的开发

AlphaScreen~(TM): A Highly Sensitive, Nonradioactive and Homogeneous Assay Platform for Drug Discovery High Throughput Screening, Genomics, and Life Science Research Applications in Miniaturized Format

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