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首页> 外文会议>American Chemical Society Meeting on Advanced Materials for Membrane Separations; 2001; Chicago,IL; US >Chemically Modified Polysulfone Hollow Fibers with Zwitterionic Sulfoalkylbetaine Group Having Improved Blood Compatibility
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Chemically Modified Polysulfone Hollow Fibers with Zwitterionic Sulfoalkylbetaine Group Having Improved Blood Compatibility

机译：具有改善的血液相容性的两性离子磺烷基甜菜碱基团的化学改性聚砜中空纤维

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摘要

Hydrophilic polysulfone membranes (SPE-PSf) were prepared by covalently bonding poly(sulfoalkylbetaine) (SPE) on the surface. The immobilized amount of SPE on SPE-PSf membranes was controlled by the SPE monomer concentration in the reaction solution. The SPE-PSf membranes were significantly more hydrophilic than unmodified polysulfone or other surface-modified polysulfone membranes due to the long hydrophilic side chain of SPE, which contributes to the hydrophilic nature of the modified PSf membranes. SPE-PSf membranes showed lower protein adsorption from a plasma solution than polysulfone and other surface-modified membranes due to the highly hydrophilic surface of the SPE-PSf membranes. The SPE-PSf membranes showed significantly lower number of adhering platelets on its surface than polysulfone and other surface-modified membranes. The hydrophilic surface of SPE-PSf membranes may suppress of platelet adhesion on the SPE-PSf membranes.
机译：亲水性聚砜膜（SPE-PSf）是通过在表面共价键合聚（磺基烷基甜菜碱）（SPE）制备的。 SPE-PSf膜上SPE的固定量由反应溶液中SPE单体的浓度控制。由于SPE的亲水侧链较长，因此SPE-PSf膜的亲水性明显高于未改性的聚砜膜或其他表面改性的聚砜膜，这有助于改性PSf膜的亲水性。由于SPE-PSf膜的亲水性很高，因此SPE-PSf膜从血浆溶液中的蛋白质吸附率比聚砜和其他表面改性膜低。与聚砜和其他经表面改性的膜相比，SPE-PSf膜在其表面的粘附血小板数量明显减少。 SPE-PSf膜的亲水性表面可能会抑制血小板粘附在SPE-PSf膜上。

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