NANOMECHANICAL SENSOR ARRAY FOR DETECTION OF BIOMOLECULAR BINDINGS-TOWARD A LABEL-FREE CLINICAL ASSAY FOR SERUM TUMOR MARKERS

机译：用于检测生物分子结合的纳米机械传感器阵列-进行无标记的血清肿瘤标志物临床检测

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A label-free technique capable of rapidly screening human blood samples simultaneously for multiple serum tumor markers would enable accurate and cost-effective diagnosis of cancer before physiological symptoms appear. Recently, microfabricated, bimaterial cantilever sensors have been demonstrated to detect DNA hybridization and antigen-antibody binding at clinically relevant concentrations. Cantilever sensors deflect measurably under the surface stress resulting when biomolecules immobilized on one surface of the sensor interact with their binding partners. We present an array of cantilever sensors (silicon nitride with a gold coated surface) capable of simultaneously interrogating 100 different biomolecular interactions.

机译：能够同时针对多种血清肿瘤标志物快速筛查人类血液样本的无标签技术，可以在出现生理症状之前准确，经济地诊断癌症。近来，已经证明了微型制造的双材料悬臂梁传感器可以在临床相关浓度下检测DNA杂交和抗原-抗体结合。当固定在传感器一个表面上的生物分子与其结合伴侣相互作用时，悬臂式传感器在表面应力作用下可测量地偏转。我们提出了一种悬臂传感器阵列（具有镀金表面的氮化硅），能够同时询问100种不同的生物分子相互作用。

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来源
《American Society of Mechanical Engineers(ASME) Integrated Nanosystems Conference: Design, Synthesis, and Applications(NANO 2004); 20040922-24; Pasadena,CA(US)》|2004年|P.27-28|共2页
会议地点 PasadenaCA(US)
作者
Min Yue; Jeanne C. Stachowiak; Henry Lin; Kenneth Castelino; Ram Datar; Karolyn Hansen; Thomas Thundat; Arup Chakraborty; Richard J. Cote; Arun Majumdar;
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Department of Mechanical Engineering University of California, Berkeley;

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正文语种 eng
中图分类半导体技术;
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1. Microfluidic surface-enhanced Raman scattering sensor with monolithically integrated nanoporous gold disk arrays for rapid and label-free biomolecular detection [J] . Ming Li, Fusheng Zhao, Jianbo Zeng, Journal of biomedical optics . 2014,第11期

机译：具有单片集成纳米多孔金盘阵列的微流体表面增强拉曼散射传感器，用于快速，无标记的生物分子检测
2. Plasmonic interferometric sensor arrays for high-performance label-free biomolecular detection [J] . Yongkang Gao, Zheming Xin, Beibei Zeng Lab on a chip . 2013,第24期

机译：等离子干涉传感器阵列，用于高性能无标记生物分子检测
3. Redox and Label-Free Array Detection of Protein Markers in Human Serum [J] . Xiliang Luo, Qiao Xu, Tim James, Analytical chemistry . 2014,第11期

机译：人体血清蛋白标记物的氧化还原和无标记阵列检测
4. NANOMECHANICAL SENSOR ARRAY FOR DETECTION OF BIOMOLECULAR BINDINGS-TOWARD A LABEL-FREE CLINICAL ASSAY FOR SERUM TUMOR MARKERS [C] . Min Yue, Jeanne C. Stachowiak, Henry Lin, American Society of Mechanical Engineers Integrated Nanosystems Conference . 2004

机译：用于检测生物分子结合的纳米机械传感器阵列 - 朝向血清肿瘤标志物的无标记临床测定
5. Sensitive, label-free biomolecular binding detection using a one-dimensional photonic crystal sensor [D] . Guo, Yunbo 2010

机译：使用一维光子晶体传感器进行灵敏的无标记生物分子结合检测
6. Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array [O] . Rachel McKendry, Jiayun Zhang, Youri Arntz, 2002

机译：纳米机械悬臂阵列上的多个无标记生物检测和定量DNA结合测定
7. Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array [O] . McKendry, Rachel, Zhang, Jiayun, Arntz, Youri, 2002

机译：纳米机械悬臂阵列上的多个无标记生物检测和定量DNA结合测定
8. Tumor Marker CA 125: The Clinical Significance of the Serum Marker CA 125 in the Management of Patients with Ovarian Cancer [R] . van der Burg, M. E. L. 1989

机译：肿瘤标志物Ca 125：血清标志物Ca 125在卵巢癌患者管理中的临床意义

NANOMECHANICAL SENSOR ARRAY FOR DETECTION OF BIOMOLECULAR BINDINGS-TOWARD A LABEL-FREE CLINICAL ASSAY FOR SERUM TUMOR MARKERS

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