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SELF-ASSEMBLY LIMITS IN STRUCTURAL PROTEINS

机译:结构蛋白的自组装极限

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摘要

A mechanics-based model is presented which predicts a "neutral annulus" for quasi-crystalline self-assembling nanostructure such as collagen fibrils, wherein transcript length, torsional and axial stiffness along with primary and quaternary protein structure limit the size to which these structures may aggregate. In the present treatment, a neutral annulus is predicted at 0.625 of the fibril radius, wherein portions of the fibril interior to the neutral annulus are in compression, balanced by portions exterior to the neutral annulus which are in tension.
机译:提出了一种基于力学的模型,该模型可预测准晶体自组装纳米结构(如胶原纤维)的“中性环面”,其中转录物长度,抗扭和轴向刚度以及一级和四级蛋白质结构限制了这些结构的尺寸骨料。在本发明的治疗中,预测中性环在原纤维半径的0.625处,其中中性环内部的原纤维内部的部分处于压缩状态,而中性环外部的处于拉伸状态的部分平衡。

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