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MICROELECTRODE DESIGN IN MEMS-BASED DEP CELL FILTRATION DEVICES

机译:基于MEMS的DEP细胞过滤装置中的微电极设计

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摘要

This paper presents the design of a MEMS-based active DEP (dielectrophoresis) cell filtration microchip for manipulating and separating biological cells. Depending on the dielectric constant and polarizability, biological cells are either attracted to or repelled from the electrodes inside a microfluidic channel. Through the optimization of electrode geometries using the finite element method (FEM), it was found that circular electrodes are capable of producing a more uniform and larger gradient of the squared electric field intensity compared to electrodes of other shapes, such as square, diamond, or triangle. FEM numerical simulation results were also used to determine 50 μm as the optimal circular electrode diameter and 25 μm as the optimal gap between electrodes.
机译:本文介绍了一种用于操纵和分离生物细胞的基于MEMS的有源DEP(介电泳)细胞过滤微芯片的设计。根据介电常数和极化率,生物细胞被微流体通道内的电极吸引或排斥。通过使用有限元方法(FEM)优化电极的几何形状,发现圆形电极与正方形,菱形,椭圆形等其他形状的电极相比,能够产生更均匀,更大的平方电场强度梯度。或三角形。有限元数值模拟结果还被用来确定50μm作为最佳圆形电极直径,而25μm作为最佳电极间距。

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