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Fibre-optic probe for fluorescence diagnostics with blood influence compensation

机译:带有血液影响补偿的用于荧光诊断的光纤探头

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To minimise the influence of blood content on the fluorescence measurements in vivo, a fibre optical probe combining fluorescence and diffuse reflectance measurements was developed. For the inverse solution of the blood content recovery, a set of neural networks trained by the Monte Carlo generated learning set was used. An approach of fluorescence measurements triggered by simultaneous real-time measurements of blood content in living tissue during moderate changes in contact pressure of the optic probe is proposed. The method allows one to decrease the necessary pressure on the probe as well as increase the repeatability of the measurements. The developed approach was verified in a series of experiments on volunteers with fluorescence excitation at 365 nm and 450 nm. The proposed technology is of particular interest in the development of new fluorescence-based optical biopsy systems.
机译:为了最小化血液含量对体内荧光测量的影响,开发了一种结合了荧光和漫反射测量的光纤探头。对于血液含量恢复的逆解,使用了一组由蒙特卡洛生成的学习集训练的神经网络。提出了一种通过在光学探头的接触压力适度变化期间同时实时测量活组织中血液含量而触发的荧光测量方法。该方法可以降低探针上的必要压力,并提高测量的可重复性。在志愿者在365 nm和450 nm荧光激发下进行的一系列实验中验证了该开发方法。所提出的技术在新的基于荧光的光学活检系统的开发中特别有意义。

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