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首页> 外文会议>Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Refined multiscale entropy analysis of heart period and QT interval variabilities in long QT syndrome type-1 patients
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Refined multiscale entropy analysis of heart period and QT interval variabilities in long QT syndrome type-1 patients

机译：长期QT综合征1型患者心脏周期和QT间期变异性的精细多尺度熵分析

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This study assesses complexity of cardiovascular control in patients affected by type-1 variant of long QT (LQT1) syndrome. Complexity was assessed by refined multiscale entropy of heart period (HP) and QT interval variabilities. HP was taken as the time distance between two consecutive R peaks (RR) and QT interval was approximated as the time distance between the R-peak and T-wave apex (RTa) and between R-peak and T-wave end (RTe). RR, RTa and RTe intervals were automatically extracted from 24h Holter recordings and the daytime period was analyzed (from 02∶00 to 06:00 PM). Non mutation carrier (NMC) individuals (n=11), utilized as a control group, were taken from the same family line of the mutation carrier (MC) subjects (n=26). We found that, while NMC and MC groups were indistinguishable based on time domain and complexity analyses of RR dynamics, complexity analysis of RTa and RTe variabilities clearly separates the two populations and suggests an impairment in the cardiac control mechanisms acting on the ventricles.
机译：这项研究评估了受长QT（LQT1）综合征1型变异影响的患者心血管控制的复杂性。通过心周期（HP）和QT间隔变异性的精细多尺度熵评估复杂性。将HP视为两个连续的R峰之间的时间距离（RR），将QT间隔近似为R峰与T波顶点之间的时间距离（RTa）和R峰与T波末端之间的时间距离（RTe） 。从24小时动态心电图记录中自动提取RR，RTa和RTe间隔，并分析白天时段（从02：00到06:00 PM）。用作对照组的非突变携带者（NMC）个体（n = 11）来自突变携带者（MC）受试者的同一家族（n = 26）。我们发现，尽管基于时域和RR动力学的复杂性分析无法区分NMC和MC组，但RTa和RTe变异性的复杂性分析清楚地将这两个人群区分开，并提示作用于心室的心脏控制机制受损。

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