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Desynchronization of neural activity in a network model

机译:网络模型中神经活动的去同步

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Electric brain activity during seizures is often associated with hyperactive and synchronous bursts of activity. We investigated different protocols of electric stimulation in a model network as potential seizure control mechanisms. Our network consisted of a chain loop of cells with excitatory synapses, representing a neocortical microcircuit. Random fluctuations of the membrane potential in each neuron simulated activity originating from other areas. Overall depolarizing and hyperpolarizing currents were not effective in stopping synchronized activity in the network. An electric current proportional to the inverted field potential was an effective desynchronizing stimulus in smaller networks.
机译:癫痫发作期间的脑电活动通常与活动过度活跃和同步爆发有关。我们调查了模型网​​络中作为潜在癫痫控制机制的电刺激的不同协议。我们的网络由具有兴奋性突触的细胞链环组成,代表新皮层微电路。来自其他区域的每个神经元模拟活动中膜电位的随机波动。总的去极化和超极化电流在阻止网络中同步活动方面无效。在较小的网络中,与反向场电位成正比的电流是有效的去同步刺激。

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