首页> 外文会议>Annual Computational Neuroscience Meeting(CNS'02); 20020721-20020725; Chicago,IL; US >Modeling the effects of nicotine on a continuous performance task
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Modeling the effects of nicotine on a continuous performance task

机译:建模尼古丁对持续执行任务的影响

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We have developed a neurocomputational model of some attentional effects of nicotine. Our simulations reproduce results showing smoking abstinence to impair performance on a rapid visual information processing task involving detecting sequences of even or odd digits. Our model treats presence of nicotine as enhancement of modulatory acetylcholine signals, which focus attention on task-relevant stimuli. Our network includes cholinergic signals from nucleus basalis; working memory representations in dorsolateral prefrontal cortex; inputs to nucleus basalis from entorhinal cortex; and recency signals. Digits are represented at entorhinal, nucleus basalis, and dorsolateral levels, along with dorsolateral representations of the concepts "even" and "odd."
机译:我们已经开发了一些尼古丁的注意力影响的神经计算模型。我们的模拟重现了显示戒烟会损害快速视觉信息处理任务(包括检测偶数或奇数数字序列)的性能的结果。我们的模型将尼古丁的存在视为调节性乙酰胆碱信号的增强,从而将注意力集中在与任务相关的刺激上。我们的网络包含来自基底核的胆碱能信号;背外侧前额叶皮层的工作记忆表现;从内嗅皮层向基底核输入;和新近度信号。数字代表内嗅,基底核和背外侧水平,以及“偶数”和“奇数”概念的背外侧表示。

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