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首页> 外文会议>Annual Symposium on Quantitative Nondestructive Evaluation; 19980719-24; Snowbird,UT(US) >ULTRASOUND STIMULATED ACOUSTIC EMISSION: PRELIMINARY IN VIVO RESULTS
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ULTRASOUND STIMULATED ACOUSTIC EMISSION: PRELIMINARY IN VIVO RESULTS

机译：超声刺激的声发射：体内结果初步

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A great deal of recent evidence has indicated a relationship between calcification in the coronary arteries and coronary heart disease. Methods such as spiral CT, electron beam CT, digital subtraction fluoroscopy, and intravascular ultrasound have been used to detect this "indicator" calcification, either directly in the coronaries or in indicator arteries such as the brachials, carotids, or illiacs. The nonzero threshold for CT detection of calcium (2 mm~2) produces a high negative predictive value for greater than 50% stenosis but relatively low positive predictive value. Conventional ultrasound, even intra-arterial, has low sensitivity and specificity for calcification but good sensitivity for intimal thickening. Recent histologic studies in vessels which have not been decalcified have shown the ubiquitous presence of calcification in the plaque, the media and the fibrous regions of diseased arteries and not normal arteries. These results indicate a place for a noninvasive method of detecting early calcification which could be used as a preventive medicine guide for at-risk individuals as mentioned by Loecker et al.. The acoustic emission imaging and spectra methods described below are candidates for such noninvasive methods. Most previous work has concentrated on multidimensional imaging of morphology, anatomy, and function directed at persons with relatively advanced disease. We now concentrate on developing imaging approaches for noninvasive preclinical diagnosis to enhance primary prevention approaches to the atherosclerotic disease.
机译：最近的大量证据表明，冠状动脉钙化与冠心病之间存在联系。诸如螺旋CT，电子束CT，数字减影透视和血管内超声之类的方法已被用于直接在冠状动脉或诸如肱，颈动脉或腔内的指示动脉中检测这种“指标”钙化。钙（2 mm〜2）的CT检测非零阈值会导致狭窄率大于50％时产生较高的阴性预测值，但阳性预测值相对较低。常规超声，甚至动脉内超声，对钙化的敏感性和特异性均较低，但对内膜增厚的敏感性较高。最近在未脱钙的血管中进行的组织学研究表明，在病变动脉的斑块，中层和纤维区域普遍存在钙化，而不是正常动脉。这些结果表明了一种用于早期钙化的无创检测方法的场所，该方法可以用作Loecker等人提到的高危人群的预防医学指南。下面描述的声发射成像和频谱方法是此类无创方法的候选方法。以前的大多数工作都集中在针对相对较晚期疾病的人的形态，解剖学和功能的多维成像上。我们现在专注于开发用于无创临床前诊断的影像学方法，以增强对动脉粥样硬化疾病的一级预防方法。

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