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首页> 外文会议>Annual TechConnect World Innovation Conference Expo;Annual Nanotech Conference Expo;National SBIR/STTR Conference >Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology
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Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology

机译：脑溶素的纳米递送减少了功能化的金纳米颗粒诱导的血脑屏障破坏，脑水肿形成和脑病理

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摘要

Recently, gold nanoparticles (AuNPs) are used for drug delivery in treating several neurological disorders e.g., Alzheimer's disease (AD), Parkinson's disease, Stroke and trauma. In addition, use of AuNPs for diagnostic purposes in various diseases are also common in clinical medicine. However, the neurotoxic effects of AuNPs in vivo studies are not well explored. In this innovation we present evidences that functionalized AuNPs induced brain pathology that depends on size, dose and route of administration. These AuNPs induce breakdown of the blood-brain barrier (BBB) permeability to protein tracers causing brain edema formation and neuronal and glial cell injuries. The magnitude and intensity of brain pathology caused by AuNPs is inversely related to the size of the NPs. Interestingly, co-administration of cerebrolysin, a balanced composition of various neurotrophic factors and active peptide fragments reduces AuNPs induced brain pathology. This effect was much more pronounced when the cerebrolysin was administered using Ti02 nanowired delivery, not reported earlier. Thus, use of cerebrolysin with or without nanowired as adjunct therapy could be used where AuNPs are used either for drug delivery or for diagnostic purposes in clinics.
机译：最近，金纳米颗粒（AuNP）被用于药物递送，以治疗几种神经系统疾病，例如阿尔茨海默氏病（AD），帕金森氏病，中风和创伤。另外，在临床医学中也普遍使用AuNP用于各种疾病的诊断目的。但是，尚未很好地研究AuNPs在体内研究中的神经毒性作用。在这项创新中，我们提供证据表明功能化的AuNPs可以诱导大脑病理，这取决于大小，剂量和给药途径。这些AuNPs导致血脑屏障（BBB）对蛋白质示踪剂的通透性下降，导致脑水肿形成以及神经元和神经胶质细胞损伤。 AuNPs引起的脑部病理学的大小和强度与NPs的大小成反比。有趣的是，脑溶素，各种神经营养因子和活性肽片段的平衡组成的共同给药减少了AuNPs引起的脑部疾病。当使用TiO 2纳米线递送施用脑溶素时，这种作用更加明显，这是先前未报道的。因此，在AuNPs用于药物递送或临床诊断目的的情况下，可以使用带有或不带有纳米线的脑溶素作为辅助疗法。

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  • 会议地点 Washington(GB)
  • 作者

    Aruna Sharma; Preeti Kumaran Menon; Dafin Fior Muresanu; Jose Vicente Lafuente; Ala Nozari; Ranjana Patnaik; Asya Ozkizilcik; Z Ryan Tian; Herbert Mossier; Hari Shanker Sharma;

  • 作者单位

    International Experimental Central Nervous System Injury Repair (IECNSIR) Dept. of Surgical Sciences Anesthesiology Intensive Care Medicine Uppsala University Hospital Uppsala University SE-75185 Uppsala Sweden RoNeuro' Institute for Neurological Research and Diagnostic 37 Mircea Eliade Street 400364 Cluj-Napoca Romania LaNCE Dpt. Neuroscience University of the Basque Country (UPV/EHU) Leioa Bizkaia Spain;

    International Experimental Central Nervous System Injury Repair (IECNSIR) Dept. of Surgical Sciences Anesthesiology Intensive Care Medicine Uppsala University Hospital Uppsala University SE-75185 Uppsala Sweden School of Biomedical Engineering Dept. of Biomaterials Indian Institute of technology Banaras Hindu University Varanasi India;

    Dept. Clinical Neurosciences University of Medicine Pharmacy Cluj-Napoca Romania RoNeuro' Institute for Neurological Research and Diagnostic 37 Mircea Eliade Street 400364 Cluj-Napoca Romania;

    LaNCE Dpt. Neuroscience University of the Basque Country (UPV/EHU) Leioa Bizkaia Spain Nanoneurosurgery Group BioCruces Health Research Institute 48903 Barakaldo Bizkaia Spain Faculty of Health Science Universidad Autonoma de Chile Santiago de Chile Chile;

    Anesthesiology Massachusetts General Hospital Harvard University Boston MA USA;

    School of Biomedical Engineering Dept. of Biomaterials Indian Institute of technology Banaras Hindu University Varanasi India;

    Department of Biomedical Engineering University of Arkansas Fayetteville AR USA;

    Dept. Chemistry Biochemistry University of Arkansas Fayetteville AR USA;

    RoNeuro' Institute for Neurological Research and Diagnostic 37 Mircea Eliade Street 400364 Cluj-Napoca Romania;

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    Functionalized gold nanoparticles; brain pathology; blood-brain barrier; brain edema; Cerebrolsyin; nanodelivery;

    机译：功能化的金纳米粒子；脑病理学血脑屏障;脑水肿;脑啡肽;纳米交付;

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