• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Asia Pacific Symposium on Safety; 20051102-04; Shaoxing(CN) >Subchronic Toxicity Evaluation of Diphenylchyanarsine in Rats
【24h】

Subchronic Toxicity Evaluation of Diphenylchyanarsine in Rats

机译：大鼠二苯并茶碱的亚慢性毒性评价

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Twenty SD rats of each sex were gavaged with either 0, 0.161, 0.323, 0.646 or 1.292 mg/kg of DC in sesame oil 6 d/wk for 13 weeks. The results indicated that after 3 weeks of exposure, salivation and even rhinorrhagia when serious intoxication occurred in partial rats of 1.292 and 0.646 mg/kg and the mean body weight of these two groups were obviously reduced during 12 to 13 weeks. During the exposure, the mean feed intakes per 100 g body weight were obviously reduced at 1.292 and 0.646 mg/kg. Analytic results of hematological indices indicated that the changes occurred in the rats exposed to 1.292, 0.646 and 0.323mg/kg of DC: significant decreases in red-cell counts, contents of haematoglobin, hematocrits and lymphocytes in hematology, a significant increase of mean concentration of haematoglobin. Analytic results of blood biochemical indices indicated the concentrations of potassium, total protein, total bilirubin, cholesterine in 1.292 and 0.646 mg/kg obviously increased too. Histopatholoic examinations revealed that hepatocyte vacuolation and inflammatory cell infiltration, lesion of mucous membrane of urnary bladder, abscission of gastric mucosa superficial lamella cells, enlarge chronic inflammatory foci of lung and degenerated change of kidney micro tubular cells, regression change of some adrenal medulla cells were presented in 1.292 mg/kg of rats. Minor injury of tubular structures in portal area of liver and hepatocytes, as well as minor shedding of stomach mucosa superficial lamella cell and slight distension of jejunum, ileum, colon could be seen in 0.646 mg/kg. A small quantity chronic inflammatory focus could been seen in lungs of 0.323mg/kg of rats. All tests in 0.161 mg/kg of rats did not show marked abnormality. We considered by comprehensive analyses that in this condition, main target organs of toxic reaction of DC on rats (ig) were liver, stomach, kidney, and it could cause and enlarge chronic inflammatory foci of lung. Estimated dose range for NOAEL appeared to be 0.161mg/kg when administered orally (ig) for 13 weeks.
机译：每只雌性20只SD大鼠在6 d / wk时分别用0、0.161、0.323、0.646或1.292 mg / kg的DC灌胃，持续13周。结果表明，暴露3周后，部分中毒的大鼠中毒时流涎甚至流鼻涕，严重时中毒为1.292和0.646 mg / kg，两组的平均体重在12至13周内明显降低。在暴露期间，每100克体重的平均采食量明显减少了1.292和0.646 mg / kg。血液学指标的分析结果表明，在暴露于1.292、0.646和0.323mg / kg DC的大鼠中发生了变化：血液学中红细胞计数，血红蛋白，血细胞比容和淋巴细胞的含量显着下降，平均浓度显着增加血红蛋白。血液生化指标分析结果表明，血钾，总蛋白，总胆红素，胆固醇含量分别为1.292和0.646 mg / kg。组织病理学检查发现，肝细胞空泡化和炎性细胞浸润，膀胱粘膜病变，胃粘膜浅层薄层细胞脱落，肺部慢性炎性灶增大，肾微管细胞变性，部分肾上腺髓质细胞退化。在1.292 mg / kg大鼠中存在。在0.646 mg / kg的剂量下，可观察到肝和肝细胞门区的管状结构受到轻微损伤，胃粘膜浅层薄层细胞轻微脱落，空肠，回肠，结肠略有扩张。在0.323mg / kg的大鼠肺中可观察到少量慢性炎性病灶。在0.161 mg / kg大鼠中的所有测试均未显示明显异常。通过综合分析，我们认为在这种情况下，DC对大鼠（ig）的毒性反应的主要靶器官是肝，胃，肾，它可能引起并扩大肺的慢性炎症灶。口服（ig）持续13周时，NOAEL的估计剂量范围似乎为0.161mg / kg。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号