Prediction of DNA-Binding Propensity of Proteins by the Ball-Histogram Method

机译：球直方图方法预测蛋白质的DNA结合倾向

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We contribute a novel, ball-histogram approach to DNA-binding propensity prediction of proteins. Unlike state-of-the-art methods based on constructing an ad-hoc set of features describing the charged patches of the proteins, the ball-histogram technique enables a systematic, Monte-Carlo exploration of the spatial distribution of charged amino acids, capturing joint probabilities of specified amino acids occurring in certain distances from each other. This exploration yields a model for the prediction of DNA binding propensity. We validate our method in prediction experiments, achieving favorable accuracies. Moreover, our method also provides interpretable features involving spatial distributions of selected amino acids.

机译：我们为蛋白质的DNA结合倾向预测提供了一种新颖的球形直方图方法。与基于构建描述蛋白质带电斑块的特有特征的最新方法不同，球形直方图技术可以对带电荷氨基酸的空间分布进行系统的蒙特卡洛探索，从而捕获特定氨基酸彼此之间有一定距离的联合概率。该探索产生了用于预测DNA结合倾向的模型。我们在预测实验中验证了我们的方法，获得了良好的准确性。此外，我们的方法还提供了涉及选定氨基酸空间分布的可解释特征。

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来源
《Bioinformatics research and applications》|2011年|p.358-367|共10页
会议地点 Changsha(CN);Changsha(CN)
作者
Andrea Szaboova; Ondrej Kuzelka; Sergio Morales E.; Filip Zelezny; Jakub Tolar;
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作者单位

Czech Technical University, Prague, Czech Republic;

Czech Technical University, Prague, Czech Republic;

Instituto Tecnologico de Costa Rica ITCR;

Czech Technical University, Prague, Czech Republic;

University of Minnesota, Minneapolis, USA;

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原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
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专利

1. Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search [J] . Andrea Szabóová, Ond?ej Ku?elka, Filip ?elezny, BMC Bioinformatics . 2012,第SUPPLEMENTa10期

机译：球直方图法使用自动模板搜索预测蛋白质的DNA结合倾向
2. Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search [J] . Andrea Szabóová, Ond?ej Ku?elka, Filip ?elezny, BMC Bioinformatics . 2012,第SUPPLEMENTa10期

机译：球直方图法使用自动模板搜索预测蛋白质的DNA结合倾向
3. A Review of DNA-binding Proteins Prediction Methods [J] . Kaiyang Qu, Leyi Wei, Quan Zou Current Bioinformatics . 2019,第3期

机译：DNA结合蛋白质预测方法的综述
4. Extending the ball-histogram method with continuous distributions and an application to prediction of DNA-binding proteins [C] . Kuzelka Ondrej, Szaboova Andrea, Zelezny Filip 2012 IEEE International Conference on Bioinformatics and Biomedicine. . 2012

机译：扩展具有连续分布的球直方图方法及其在DNA结合蛋白预测中的应用
5. Computational methods for protein -protein complex structure prediction and mass spectrometry-based protein identification [D] . Tong, Weiwei 2008

机译：蛋白质-蛋白质复合物结构预测和基于质谱的蛋白质鉴定的计算方法
6. Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search [O] . Andrea Szabóová, Ondřej Kuželka, Filip Železný, 2012

机译：球直方图法使用自动模板搜索预测蛋白质的DNA结合倾向
7. Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search [O] . Andrea Szabóová, Ondřej Kuželka, Filip železnŷ, 2012

机译：球直方图法使用自动模板搜索预测蛋白质的DNA结合倾向

Prediction of DNA-Binding Propensity of Proteins by the Ball-Histogram Method

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