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首页> 外文会议>Biomedical Applications of Micro- and Nanoengineering II; Progress in Biomedical Optics and Imaging; vol.5 no.34 >Development of blood extraction system designed by female mosquito's blood sampling mechanism for Bio-MEMS
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Development of blood extraction system designed by female mosquito's blood sampling mechanism for Bio-MEMS

机译：由女性蚊子采血机理设计的生物MEMS采血系统的开发

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A compact and wearable wristwatch type Bio-MEMS such as a health monitoring system (HMS) to detect blood sugar level for diabetic patient, was newly developed. The HMS consists of (1) a indentation unit with a microneedle to generate the skin penetration force using a shape memory alloy(SMA) actuator, (2) a pumping unit using a bimorph PZT piezoelectric actuator to extract the blood and (3) a gold (Au) electrode as a biosensor immobilized GOx and attached to the gate electrode of MOSFET to detect the amount of Glucose in extracted blood. GOx was immobilized on a self assembled spacer combined with an Au electrode by the cross-link method using BSA as an additional bonding material. The device can extract blood in a few microliter through a painless microneedle with the negative pressure by deflection of the bimorph PZT piezoelectric actuator produced in the blood chamber, by the similar way the female mosquito extracts human blood with muscle motion to flex or relax. The performances of the liquid sampling ability of the pumping unit through a microneedle (3.8mm length, 100 μm internal diameter) using the bimorph PZT piezoelectric microactuator were measured. The blood extraction micro device could extract human blood at the speed of 2 μl/min, and it is enough volume to measure a glucose level, compared to the amount of commercial based glucose level monitor. The electrode embedded in the blood extraction device chamber could detect electrons generated by the hydrolysis of hydrogen peroxide produced by the reaction between GOx and glucose in a few microliter extracted blood, using the constant electric current measurement system of the MOSFET type hybrid biosensor. The output voltage for the glucose diluted in the chamber was increased lineally with increase of the glucose concentration.
机译：新开发了一种紧凑且可穿戴的手表型Bio-MEMS，例如用于检测糖尿病患者血糖水平的健康监测系统（HMS）。 HMS包括（1）带有微针的压痕单元，使用形状记忆合金（SMA）驱动器产生皮肤穿透力;（2）使用双压电晶片PZT压电驱动器抽取血液的泵浦单元;（3）金（Au）电极作为固定GOx的生物传感器，并连接到MOSFET的栅电极以检测提取的血液中的葡萄糖量。通过使用BSA作为附加粘合材料的交联方法，将GOx固定在与Au电极结合的自组装垫片上。该装置可通过在血腔中产生的双压电晶片PZT压电致动器的偏转，通过负压通过无痛的微针抽取几微升的血液，类似于雌性蚊子通过肌肉运动来抽取人体血液以使其弯曲或放松。使用双压电晶片PZT压电微致动器，测量了通过微针（长度为3.8mm，内径为100μm）的抽油机的液体采样性能。血液提取微设备可以以2μl/ min的速度提取人血液，与基于商用血糖水平监测仪的量相比，它的体积足以测量葡萄糖水平。使用MOSFET型混合生物传感器的恒流测量系统，嵌入血液提取装置腔室中的电极可以检测到在几微升提取的血液中GOx与葡萄糖之间的反应产生的过氧化氢水解产生的电子。随着葡萄糖浓度的增加，腔室中稀释的葡萄糖的输出电压线性增加。

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