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首页> 外文会议>Biomedical and Health Informatics (BHI), 2012 IEEE-EMBS International Conference on >Reflex activities of the urinary bladder in intact and spinally transected rats with bladder filling and sacral neuromodulation
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Reflex activities of the urinary bladder in intact and spinally transected rats with bladder filling and sacral neuromodulation

机译：完整和脊柱横断大鼠膀胱充盈和神经调节后膀胱的反射活动

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摘要

The aim of this study was to investigate the bladder responses with different grades of bladder filling in intact and spinal cord injury (SCI) rats. The study also examined the effects of sacral neuromodulation (SNM) on bladder reflex responses in the rat model following complete SCI. Eight adult female Sprague Dawley rats were divided into three groups: group 1, intact rats (n=4); group 2, spinally transected (T9–T10) rats (n=4); group 3, spinally transected rats with SNM treatment (n=1). For group 3, the rats were treated by SNM for 6 hours with the cathode electrode placed in the S1 foramen unilaterally. The intravesical pressure induced by continuous infusion of saline with different grades under general anesthesia was recorded in all groups. The SCI rats displayed neurogenic detrusor overactivity characterized by non-voiding contractions during bladder filling. The bladder contractions in the SCI rats, unlike in the intact rats, were independent of the rate of bladder filling. With SNM, the peak intravesical pressure was increased, indicating an improvement of bladder reflex function. These data are discussed in the context of understanding the bladder reflex activity before and after SCI, as well as the effects with SNM.
机译：这项研究的目的是调查完整和脊髓损伤（SCI）大鼠不同程度的膀胱充盈的膀胱反应。这项研究还研究了完全SCI后，model神经调节（SNM）对大鼠模型膀胱反射反应的影响。将八只成年雌性Sprague Dawley大鼠分为三组：第1组，完整大鼠（n = 4）；第3组，第3组。第2组，脊髓横断（T9–T10）大鼠（n = 4）；第3组，脊髓横断大鼠接受SNM治疗（n = 1）。对于第3组，将大鼠的阴极单侧置于S1孔中，用SNM处理6小时。所有组均记录了在全身麻醉下连续输注不同等级的盐水引起的膀胱内压。 SCI大鼠表现出神经源性逼尿肌过度活动，其特征是在膀胱充盈过程中出现无孔收缩。与完整大鼠不同，SCI大鼠的膀胱收缩与膀胱充盈率无关。使用SNM时，峰值膀胱内压力增加，表明膀胱反射功能得到改善。在了解SCI之前和之后的膀胱反射活动以及SNM的影响的背景下讨论了这些数据。

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