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首页> 外文会议>Biomedical Science amp; Engineering Conference, 2009. BSEC 2009 >Deletion of the gelatinase MMP-2 affects the compositional and biomechanical properties of bone
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Deletion of the gelatinase MMP-2 affects the compositional and biomechanical properties of bone

机译：明胶酶MMP-2的缺失会影响骨骼的组成和生物力学特性

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While determinants independent of bone mass have been identified for bone strength and toughness, little is known about genetic regulation of these factors, referred to collectively as bone quality. In the present work, using a mouse model, we investigated whether the deletion of the gene coding for matrix metalloproteinase-2 (MMP-2) could affect the structural, compositional, and biomechanical properties of cortical bone. Analysis by micro-computed tomography of the femur of 8-week and 16-week old, male mice revealed that the loss of MMP-2 caused thinner cortices but had no effect on moment of inertia. Regardless of age, the MMP-2 null femurs had lower modulus and strength than the wild-type femurs. This effect was likely related to the decrease in bone mineral density and mineral-to-collagen ratio that was observed for the knock-out femurs. Enzymes important for the turnover of collagen may be important to bone quality.
机译：尽管已经确定了与骨骼质量无关的决定因素来确定骨骼的强度和韧性，但是对这些因素的遗传调控知之甚少，这些因素统称为骨骼质量。在目前的工作中，使用小鼠模型，我们调查了编码基质金属蛋白酶2（MMP-2）的基因的缺失是否会影响皮质骨的结构，组成和生物力学特性。通过对8周龄和16周龄的雄性小鼠的股骨进行微计算机断层扫描分析，发现MMP-2的缺失导致皮质变薄，但对惯性矩没有影响。无论年龄大小，MMP-2无效股骨的模量和强度均低于野生型股骨。这种作用可能与敲除股骨所观察到的骨矿物质密度和矿物质胶原蛋白比的降低有关。对胶原蛋白更新至关重要的酶可能对骨骼质量很重要。

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