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首页> 外文会议>Biophotonics and Immune Responses II; Progress in Biomedical Optics and Imaging; vol.8 no.15; Proceedings of SPIE-The International Society for Optical Engineering; vol.6438 >Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment
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Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment

机译：通过MRI和激光免疫学测量组织温度分布以治疗癌症

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In cancer treatment and immune response enhancement research, Magnetic Resonance Imaging (MRI) is an ideal method for non-invasive, three-dimensional temperature measurement. We used a 7.1-Tesla magnetic resonance imager for ex vivo tissues and small animal to determine temperature distribution of target tissue during laser irradiation. The feasibility of imaging is approved with high spatial resolution and high signalnoise-ratio. Tissue-simulating gel phantom gel, biological tissues, and tumor-bearing animals were used in the experiments for laser treatment and MR imaging. Thermal couple measurement of temperature in target samples was used for system calibration. An 805-nm laser was used to irradiate the samples with a laser power in the range of 1 to 2.5 watts. Using the MRI system and a specially developed processing algorithm, a clear temperature distribution matrix in the target tissue and surrounding tissue was obtained. The temperature profiles show that the selective laser photothermal effect could result in tissue temperature elevation in a range of 10 to 45℃. The temperature resolution of the measurement was about 0.37℃ including the total system error. The spatial resolution was 0.4 mm (128×128 pixels with field of view of 5.5×5.5 cm). The temperature distribution provided in vivo thermal information and future reference for optimizing dye concentration and irradiation parameters to achieve optimal thermal effects in cancer treatment.
机译：在癌症治疗和免疫应答增强研究中，磁共振成像（MRI）是非侵入性三维温度测量的理想方法。我们对离体组织和小动物使用了7.1-特斯拉磁共振成像仪，以确定激光照射过程中目标组织的温度分布。高空间分辨率和高信噪比证明了成像的可行性。实验中使用组织模拟凝胶幻像凝胶，生物组织和荷瘤动物进行激光治疗和MR成像。目标样品中温度的热电偶测量用于系统校准。使用805 nm的激光以1到2.5瓦的激光功率照射样品。使用MRI系统和专门开发的处理算法，可以在目标组织和周围组织中获得清晰的温度分布矩阵。温度曲线表明，选择性激光光热效应可导致组织温度升高10至45℃。包括整个系统误差在内，测量的温度分辨率约为0.37℃。空间分辨率为0.4毫米（128×128像素，视场为5.5×5.5厘米）。温度分布提供了体内热信息，并为将来优化染料浓度和辐照参数提供参考，以在癌症治疗中获得最佳的热效应。

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