• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Biophotonics and Immune Responses II; Progress in Biomedical Optics and Imaging; vol.8 no.15; Proceedings of SPIE-The International Society for Optical Engineering; vol.6438 >Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis
【24h】

Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis

机译：咪喹莫特免疫疗法和ALA光动力疗法联合治疗生殖器弓形丘疹

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To investigate the feasibility and efficacy of combination of imiquimod immunotherapy and 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for the treatment of genital bowenoid papulosis (BP). Materials and methods: A total of twenty seven BP patients were randomized into two groups: (Ⅰ) fifteen patients (12 male and 3 female, age 22-56 years old) were treated with topical application of 5% imiquimod cream (three times a week) and ALA-PDT (100 J/cm~2 at 100 mW/cm~2, once a week) for 1 - 4 times in one week interval. (Ⅱ) Twelve patients (6 male and 6 female, age 29-58 years old) were treated with CO_2 laser vaporization as a control. Patients were followed up for 3 to 12 months. Results: In combined therapy group, 60% (9/15) patients showed complete remission and only one recurred (11.1%) during follow up. Local side effects included mild erythema, edema, erosion and burning and/or stinging sensation. No systemic side effect was found. In CO_2 laser vaporization group, 83.3% (10/12) patients showed complete remission. However, recurrence occurred in 6 patients (60.0%). Local side effects included mild to moderate edema, erosion, ulceration, delayed healing, prolonged pain and scarring. The difference of recurrence rate between two groups was statistically significant (P < 0.05). Conclusion: Topical application of imiquimod cream and ALA-PDT is safe, effective and associated with low recurrence and less side effect. Its true clinical value needs to be further investigated by a long-term follow-up of large scale trial.
机译：目的：探讨咪喹莫特免疫疗法和5-氨基乙酰丙酸介导的光动力疗法（ALA-PDT）联合治疗生殖道弓形丘疹（BP）的可行性和有效性。材料和方法：总共将277例BP患者随机分为两组：（Ⅰ）15例患者（男12例，女3例，年龄22-56岁）接受了5％咪喹莫特乳膏的局部应用治疗（3次，每次3次）。一周）和ALA-PDT（100 J / cm〜2，100 mW / cm〜2，每周一次），每隔一周间隔1-4次。 （Ⅱ）以CO_2激光汽化治疗12例（男6例，女6例，年龄29-58岁）。对患者进行了3至12个月的随访。结果：在联合治疗组中，60％（9/15）的患者表现出完全缓解，随访期间仅复发1例（11.1％）。局部副作用包括轻度红斑，浮肿，糜烂和烧灼感和/或刺痛感。未发现全身性副作用。在CO_2激光汽化组中，有83.3％（10/12）的患者显示完全缓解。但是，有6例（60.0％）复发。局部副作用包括轻度至中度水肿，糜烂，溃疡，愈合延迟，长时间疼痛和疤痕形成。两组复发率差异有统计学意义（P <0.05）。结论：咪喹莫特乳膏和ALA-PDT局部应用安全，有效，且复发率低，副作用少。其真正的临床价值需要通过大规模试验的长期随访来进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号