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Photo-nano immunotherapy for metastatic breast cancer using synergistic single-walled carbon nanotubes and glycated chitosan

机译:使用协同单壁碳纳米管和糖化壳聚糖的光纳米免疫疗法治疗转移性乳腺癌

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摘要

In our previous work, we constructed a multifunctional nano system, using single-walled carbon nanotube (SWNT) and glycated chitosan (GC), which can synergize photothermal and immunological effects. To further confirm the therapy efficacy, with a metastatic mouse mammary tumor model (4T1), we investigate the therapy effects and immune response induced by SWNT-GC, under laser irradiation. Laser+SWNT-GC treatment not only suppressed the prime tumor, but also induced antitumor immune response. It could be developed into a promising treatment modality for the metastatic breast cancer.
机译:在我们之前的工作中,我们使用单壁碳纳米管(SWNT)和糖化壳聚糖(GC)构建了多功能纳米系统,可以协同发挥光热和免疫学作用。为进一步证实治疗效果,采用转移性小鼠乳腺肿瘤模型(4T1),我们研究了激光照射下SWNT-GC诱导的治疗效果和免疫应答。激光+ SWNT-GC治疗不仅抑制了原发肿瘤,而且还诱导了抗肿瘤免疫反应。它可以发展成为一种有前途的转移性乳腺癌治疗方法。

著录项

  • 来源
    《Biophotonics and immune responses X》|2015年|93240L.1-93240L.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者单位

    Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA;

    Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA;

    Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA;

    Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA;

    Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA;

    Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    SWNT-GC; laser; breast metastatic cancer;

    机译:SWNT-GC;激光;乳腺转移癌;

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