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Real-time monitoring of tumor response to preoperative radiochemotherapy for rectal carcinoma by nonlinear optical microscopy

机译：非线性光学显微镜实时监测直肠癌术前放化疗对肿瘤的反应

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摘要

The continuing advancement of nonlinear optical imaging techniques has opened many new windows in biological exploration. In this work, the nonlinear optical microscopy, based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG), was extended to probe tumor response to preoperative radiochemotherapy (RCT) for rectal carcinoma. It was found that MPM has the ability of direct visualization of histopathologic changes in rectal carcinoma following preoperative RCT including stromal fibrosis, colloid response and residual tumors. Our results also showed the capability of MPM using the quantitative analyses of images to quantify these changes. This work may provide the groundwork for further exploration into the application of multiphoton-based endoscopy in a clinical setting.
机译：非线性光学成像技术的不断发展为生物探索打开了许多新窗口。在这项工作中，扩展了基于双光子激发荧光（TPEF）和二次谐波产生（SHG）的非线性光学显微镜，以探测对直肠癌术前放射化学疗法（RCT）的肿瘤反应。已发现MPM能够直接可视化术前RCT后直肠癌的组织病理学变化，包括基质纤维化，胶体反应和残留肿瘤。我们的结果还显示了使用图像的定量分析来量化这些变化的MPM的能力。这项工作可为进一步探索基于多光子的内窥镜在临床中的应用提供基础。

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  • 来源
    《Biophotonics and immune responses X》|2015年|93240R.1-93240R.7|共7页
  • 会议地点 San Francisco CA(US)
  • 作者

    Lianhuang Li; Zhifen Chen; Xingfu Wang; Weizhong Jiang; Guoxian Guan; Jianxin Chen;

  • 作者单位

    Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

    Department of Colorectal Surgery, The Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, China;

    Department of Pathology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350001, China;

    Department of Colorectal Surgery, The Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, China;

    Department of Colorectal Surgery, The Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, China;

    Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Preoperative radiochemotherapy (RCT); rectal carcinoma; two-photon excited fluorescence (TPEF); second harmonic generation (SHG);

    机译：术前放化疗（RCT）;直肠癌双光子激发荧光（TPEF）；二次谐波（SHG）;

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