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Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research

机译:新生儿颅内出血的光学成像:现代诊断方法和未来研究方向

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Using Doppler optical coherence tomography (DOCT) we study stress-related intracranial hemorrhages (ICHs) in newborn rats. We investigate a masked stage of ICH development that corresponds to the first 4 h after the stress. We show that this period is characterized by significant changes in the diameter of the sagittal vein and the velocity of the cerebral venous blood flow (CVBF). We discuss diagnostic abilities of wavelet-based methods and consider an adaptive technique allowing us to reveal clearest distinctions in the dynamics of CVBF between normal and stressed newborn rats. Finally, we conclude that the venous insufficiency in newborns and a reduced response of the sagittal vein to adrenaline are related to important prognostic markers of the risk of ICH development.
机译:使用多普勒光学相干断层扫描(DOCT),我们研究了新生大鼠中与压力有关的颅内出血(ICH)。我们调查了与压力后的最初4小时相对应的ICH发展的掩盖阶段。我们表明,这一时期的特征是矢状静脉直径和脑静脉血流速度(CVBF)的显着变化。我们讨论基于小波的方法的诊断能力,并考虑一种自适应技术,使我们能够揭示正常和压力新生大鼠之间CVBF动态的最明显区别。最后,我们得出结论,新生儿静脉功能不全和矢状静脉对肾上腺素的反应减少与ICH发生风险的重要预后指标有关。

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