• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis >Evaluation of variations in Plasma Collagen NADH and Flavin in Pre and Post Treated Breast Cancer patients Using Native Fluorescence Spectroscopy
【24h】

Evaluation of variations in Plasma Collagen NADH and Flavin in Pre and Post Treated Breast Cancer patients Using Native Fluorescence Spectroscopy

机译：使用天然荧光光谱法评估治疗前后的乳腺癌患者血浆胶原NADH和黄素的变化

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Optical spectroscopic techniques based on tissues, cell lines and biofluids for the detection of cancer and variousdisorders are being extensively opted due to their high sensitivity, ease of procedure and sample preparation.Though the use of fluorescence in the field of oncology started as early as 1924 by Policard et al, the use ofNative Fluorescence Spectroscopy (NFS) as a tool for cancer diagnosis and treatment monitoring, has shownsignificant progress only in the recent years, due to the advancements in the detection system and software.Even though an array of chemotherapeutic agents and sophisticated Radiotherapy techniques have evolved inthe management of cancers, surgery is mostly opted as the first line of treatment in most of the breast cancercases, in an approach to remove the bulk of tumour from the body. The goal of this study is to assess theefficacy of various treatment modalities, in this case surgery (modified radical mastectomy) and chemotherapyby comparing the NF spectra of breast cancer patients, post-surgery with those on completion of chemotherapyand normal subjects. In this pilot work, NF spectroscopy of blood plasma of clinically confirmed 43 breastcancer patients were measured under pre-treatment, post-surgical, post chemotherapy and also during yearlyfollow-up (after completion of the entire treatment) conditions. The NFS spectra of 60 normal subjects were alsorecorded for comparison. The results indicate that there is a statistical significance in the spectral variations inthe region of collagen, elastin and NADH between the normal and cancer patient’s blood plasma as well asbetween pre and post treated cases as well as those patients on yearly follow-up after completion of the entiretreatment.
机译：基于组织，细胞系和生物流体的光谱技术用于检测癌症和各种疾病，由于其高灵敏度，易于操作和样品制备而被广泛选择。\ r \ n尽管在现场使用荧光Policard等人最早于1924年开始进行肿瘤学研究，使用自然荧光光谱法（NFS）作为癌症诊断和治疗监测工具，仅在最近几年才显示出重要进展，这是由于检测系统和软件的进步。\ r \ n即使在癌症管理方面已经发展出了一系列化学治疗剂和先进的放射疗法技术，在大多数乳腺癌中，大多数情况下还是选择手术作为第一线治疗方法\在某些情况下，这是一种从体内清除大部分肿瘤的方法。这项研究的目的是通过比较乳腺癌患者，手术后和完成后的患者的NF谱图，评估在这种情况下的手术（改良根治性乳房切除术）和化学疗法的各种治疗方式的有效性。化疗\ r \ n和正常人。在这项先导工作中，在治疗前，手术后，化疗后以及每年的随访期间（在整个治疗完成之后），对临床确诊的43名乳腺癌\ r \ n癌症患者的血浆NF光谱进行了测量） 条件。还记录了60名正常受试者的NFS光谱用于比较。结果表明，正常人和癌症患者血浆之间以及治疗前后患者以及这些患者之间胶原蛋白，弹性蛋白和NADH区域的光谱变化具有统计学意义。在完成整个治疗后进行年度随访。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号