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首页> 外文会议>Biosensing and nanomedicine VII >Incorporation of photosenzitizer hypericin into synthetic lipid-based nano-particles for drug delivery and large unilamellar vesicles with different content of cholesterol
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Incorporation of photosenzitizer hypericin into synthetic lipid-based nano-particles for drug delivery and large unilamellar vesicles with different content of cholesterol

机译：将光敏剂金丝桃素掺入合成的基于脂质的纳米颗粒中以用于药物输送以及具有不同胆固醇含量的大单层囊泡

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摘要

Low-density lipoproteins (LDL) and high-density lipoproteins (HDL) are attractive natural occurring vehicles for drug delivery and targeting to cancer tissues. The capacity of both types of the lipoproteins to bind hydrophobic drugs and their functionality as drug carriers have been examined in several studies and it has been also shown that mixing of anticancer drugs with LDL or HDL before administration led to an increase of cytotoxic effects of the drugs in the comparison when the drugs were administered alone. However, a difficult isolation of the lipoproteins in large quantity from a biological organism as well as a variability of the composition and size of these molecules makes practical application of LDL and HDL as drug delivery systems quite complicated. Synthetic LDL and HDL and large unilamellar vesicles (LUV) are potentially suitable candidates to substitute the native lipoproteins for targeted and effective drug delivery. In this work, we have studied process of an association of potent photosensitizer hypericin (Hyp) with synthetic lipid-based nano-particles (sLNP) and large unilamellar vesicles (LUV) containing various amount of cholesterol. Cholesterol is one of the main components of both LDL and HDL particles and its presence in biological membranes is known to be a determining factor for membrane properties. It was found that the behavior of Hyp incorporation into sLNP particles with diameter ca ～ 90 nm is qualitatively very similar to that of Hyp incorporation into LDL (diameter ca. 22 nm) and these particles are able to enter U-87 MG cells by endocytosis. The presence of cholesterol in LUV influences the capacity of these vesicles to incorporate Hyp into their structure.
机译：低密度脂蛋白（LDL）和高密度脂蛋白（HDL）是用于药物输送和靶向癌组织的有吸引力的天然载体。在数项研究中都检查了两种类型的脂蛋白结合疏水性药物的能力及其作为药物载体的功能，并且还表明，在给药前将抗癌药物与LDL或HDL混合会导致药物的细胞毒性作用增加。比较当单独使用药物时的药物。然而，难以从生物体中大量分离脂蛋白以及这些分子的组成和大小的可变性使得LDL和HDL作为药物递送系统的实际应用非常复杂。合成的LDL和HDL以及大的单层囊泡（LUV）可能是替代天然脂蛋白用于靶向和有效药物递送的潜在候选药物。在这项工作中，我们研究了强效光敏剂金丝桃素（Hyp）与合成的基于脂质的纳米颗粒（sLNP）和含有各种胆固醇的大单层囊泡（LUV）的关联过程。胆固醇是LDL和HDL颗粒的主要成分之一，已知其在生物膜中的存在是决定膜性能的因素。研究发现，Hyp掺入直径约90 nm的sLNP颗粒的行为在质量上与Hyp掺入直径约22 nm的LDL的行为非常相似，并且这些颗粒能够通过内吞作用进入U-87 MG细胞。 LUV中胆固醇的存在会影响这些囊泡将Hyp纳入其结构的能力。

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  • 来源
    《Biosensing and nanomedicine VII》|2014年|916604.1-916604.12|共12页
  • 会议地点 San Diego CA(US)
  • 作者

    Jaroslava Joniova; Ludmila Blascakova; Daniel Jancura; Zuzana Nadova; Franck Sureau; Pavol Miskovsky;

  • 作者单位

    Department of Biophysics, University of P.J. Safarik, Kosice, Slovak Republic, Laboratoire Jean Perrin, Universite Pierre et Marie Curie, Paris, France;

    Department of Biophysics, University of P.J. Safarik, Kosice, Slovak Republic;

    Department of Biophysics, University of P.J. Safarik, Kosice, Slovak Republic, Center for Interdisciplinary Biosciences, University of P.J. Safarik, Kosice, Slovak Republic;

    Department of Biophysics, University of P.J. Safarik, Kosice, Slovak Republic, Center for Interdisciplinary Biosciences, University of P.J. Safarik, Kosice, Slovak Republic;

    Laboratoire Jean Perrin, Universite Pierre et Marie Curie, Paris, France;

    Department of Biophysics, University of P.J. Safarik, Kosice, Slovak Republic, Center for Interdisciplinary Biosciences, University of P.J. Safarik, Kosice, Slovak Republic;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    drug delivery; low-density lipoproteins; synthetic lipid-based nano-particles; photodynamic therapy; hypericin; cholesterol;

    机译：药物输送；低密度脂蛋白合成脂质基纳米颗粒；光动力疗法；金丝桃素胆固醇;

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