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首页> 外文会议>Conference on Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies >Determining of platinum from hair, urine and blood samples with Graphite Furnace Atomic Absorption Spectroscopy at patients with chemotherapy
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Determining of platinum from hair, urine and blood samples with Graphite Furnace Atomic Absorption Spectroscopy at patients with chemotherapy

机译：石墨炉原子吸收光谱法测定化疗患者头发，尿液和血液中的铂

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Platinum is a malleable, ductile metal, silvery white, with atomic number 78 and atomic weight 195.09. We can find it in nature mainly as isotopes: Pt194 (32.9%), Ptl95 (33.8%) si Ptl96 (25.3%). Of all platinum metals, platinum has the most uses and it's the most abundant and most easily to be processed. Its use in auto catalysts results in environmental contamination of crowded cities and high-traffic roads. In medicine, Pt is used as a cytostatic drug. Specific platinum complexes, especially cis - diamminedichloroplatinum (Ⅱ) (cisplatin), Cis-[oxalate (trans-1-1,2- diaminocyclohexane)] platinum(Ⅱ) (oxaliplatin) and cis-diammine (1,1-cyclobutanedicarboxylato) platinum(Ⅱ) (carboplatin), used in therapeutic practice. Determination of the Pt concentration in biological samples provides medical personnel with useful information on the efficacy of the cytostatic treatment. An optoelectronic method for determining the concentration of Pt in urine, blood and hair samples collected from patients undergoing cytostatic treatment with platinum-based products is presented. To determine the concentration of Pt in biological products was used: Atomic Absorption Spectrometer model AAS-880, Atomization in the graphite furnace model GT 100, Programable Sample Dispenser PSD - Varian. Platinum concentrations of biological samples collected from platinum, based cytotoxic patients are presented. The presented method can be used to monitor platinum-based chemotherapy with platinum compounds. Graphite Furnace Atomic Absorption Spectroscopy (GF-AAS) method presented is sensitive, reproducible, and relatively easy to apply with an acceptable cost.
机译：铂金是一种可延展的易延展金属，银白色，原子序数78，原子量195.09。我们在自然界中发现的主要是同位素：Pt194（32.9％），Ptl95（33.8％）和Ptl96（25.3％）。在所有铂金属中，铂具有最多的用途，是最丰富且最容易加工的。它在汽车催化剂中的使用导致拥挤的城市和人流量大的道路对环境的污染。在医学上，Pt被用作抑制细胞生长的药物。特定的铂络合物，尤其是顺式-二氨基二氯铂（Ⅱ）（顺铂），顺式[草酸（反式1，1，2-二氨基环己烷）]铂（Ⅱ）（草酸铂）和顺式二胺（1，1-环丁烷二羧基铂）铂（Ⅱ）（卡铂），用于治疗实践。测定生物样品中的Pt浓度可为医务人员提供有关细胞抑制治疗功效的有用信息。提出了一种光电方法，用于确定从接受铂类产品细胞抑制治疗的患者收集的尿液，血液和头发中的Pt浓度。为了确定生物产品中Pt的浓度，使用了：AAS-880型原子吸收光谱仪，GT 100型石墨炉中的原子化法，可编程样品分配器PSD-Varian。介绍了从铂类细胞毒性患者收集的生物样品中的铂浓度。提出的方法可用于监测铂化合物的铂基化学疗法。提出的石墨炉原子吸收光谱法（GF-AAS）灵敏，可重现并且相对容易以可接受的成本进行应用。

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