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首页> 外文会议>Conference on Nanophotonics and Micro/Nano Optics >Quantitative analysis of ceftazidime using SERS based on silver nanoparticles substrate
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Quantitative analysis of ceftazidime using SERS based on silver nanoparticles substrate

机译：基于银纳米颗粒基质的SERS头孢他啶定量分析

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With the increasing abuse of antibiotics, more attention has been focused on the potential harm on ecological environment and human health. The aim of this study was quantitative analysis of ceftazidime using Surface Enhanced Raman spectroscopy (SERS). Flower-shaped silver nanoparticles adsorbed on silicon wafer were fabricated in an aqueous medium without heavy metal or organic wastes. The limits of detection (LOD) of Rhodamine 6G (R6G) could reached to 10~(-9) M, indicating that the substrates had high SERS activity. Meanwhile, the substrates showed excellent stability and uniformity. Flower-shaped silver nanoparticles substrates were selected as substrates for detecting the SERS spectra of ceftazidime in different concentrations. The information about the structure of ceftazidime molecule was reflect by Raman vibration assignments efficiently. Based on the Raman characteristic bands of ceftazidime. four quantitative analysis models using linear regression were compared. It was found that equation between log_(10)C (C refers to the concentration of ceftazidime) and I_(avg) (average intensity) of Raman characteristic bands (749 cm~(-1), 850 cm~(-1) and 1025 cm~(-1)) was more suitable for quantitative analysis of ceftazidime. and correlation coefficient R~2 was up to 0.96. The quantitative model was used to detect the concentration of ceftazidime in practical surface water sample (10~(-2) g/L), and the relative error between actual values and calculated values was 1.95%. This method is high sensitivity and rapid, which is potentially a powerful tool for quantitative analysis of other antibiotics.
机译：随着抗生素滥用的增加，更多的注意力集中在对生态环境和人类健康的潜在危害上。这项研究的目的是使用表面增强拉曼光谱（SERS）对头孢他啶进行定量分析。在没有重金属或有机废物的水性介质中制备了吸附在硅片上的花状银纳米颗粒。罗丹明6G（R6G）的检出限（LOD）可以达到10〜（-9）M，表明底物具有较高的SERS活性。同时，基材显示出优异的稳定性和均匀性。以花状银纳米颗粒为底物，以检测不同浓度的头孢他啶的SERS光谱。头孢他啶分子的结构信息可通过拉曼振动分配有效地反映出来。基于头孢他啶的拉曼特征谱带。比较了使用线性回归的四个定量分析模型。发现log_（10）C（C表示头孢他啶的浓度）和拉曼特征谱带（749 cm〜（-1），850 cm〜（-1）和I_（avg）（平均强度）之间的等式1025 cm〜（-1））更适合用于头孢他啶的定量分析。相关系数R〜2高达0.96。定量模型用于检测实际地表水样品中头孢他啶的浓度（10〜（-2）g / L），实际值与计算值的相对误差为1.95％。该方法灵敏，快速，可能是其他抗生素定量分析的有力工具。

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