Development and optimization of propafenone hydrochloride sustained release pellets using central composite design

机译：使用中央复合设计开发和优化盐酸普罗帕酮缓释微丸

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Extrusion-spheronization and coating with Eudragit~R NE30D dispersion were shown to be an appropriate method to produce sustained release pellets. Central composite design was successfully used to optimize the formulation of sustained release pellet of propafenone hydrochloride. The pellets comply with the requirements of the experiment design.

机译：挤出滚圆法和Eudragit〜R NE30D分散体包衣被证明是生产缓释微丸的合适方法。中心复合设计成功用于优化盐酸普罗帕酮缓释微丸的配方。颗粒符合实验设计的要求。

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来源
《China-Japan Symposium on Pharmaceutical Preparations and Particulate Design; 20060515-17; Shenyang(CN)》|2006年|P.116-117|共2页
会议地点 Shenyang(CN)
作者
Jie Yu; Meijuan Zou; Chunxia Deng; Gang Cheng;
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作者单位

School of Pharmacy, Shenyang Pharmaceutical University;

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会议组织
原文格式 PDF
正文语种 eng
中图分类制药化学工业;
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机译：1.开发热熔性包衣，应用于缓释胶囊和防篡改包衣。 2.配制维拉帕米氯化氢和地尔硫卓氯化氢半固体基质胶囊。 3.格列吡嗪的新型缓释片剂：包衣药物珠的压缩，制剂，溶解和卷积。 4.维拉帕米缓释剂：新配方和卷积剂。
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Development and optimization of propafenone hydrochloride sustained release pellets using central composite design

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