ENHANCED IN VITRO PECUTANEOUS ABSORPTION OF DICLOFENAC ACID BY COMPLEXATION WITH ALKANOLAMINES

机译：链烷醇配合物增强双氯芬酸的体外意外吸收

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The preparation of diclofenac acid (DA) - alkanolamine (diethanolamine, triethanolamine, N-(2-Hydroxyethyl) piperidine) complexes was tempted to increase the transdermal flux of DA. DSC and FT-IR studies demonstrated that DCF and each alkanolmine formed an ion pair complex. The series of alkanolamine complexs had a lower melting point and higher solubility in water compared to pure DA. A lipophilic enhancer system consisting of isopropyl myristate and and ethanol (9:1; EI system) produced a marked enhancement of DA flux from the alkanolamine complexes through rat skin membrane. Among the complex examined, the diclofenac diethanolamine had the greatest enhancing effect on the permeation of DA.

机译：尝试制备双氯芬酸（DA）-链烷醇胺（二乙醇胺，三乙醇胺，N-（2-羟乙基）哌啶）复合物以增加DA的透皮通量。 DSC和FT-IR研究表明DCF和每个链烷醇胺形成离子对络合物。与纯DA相比，该系列烷醇胺配合物具有较低的熔点和较高的水溶性。由肉豆蔻酸异丙酯和乙醇组成的亲脂性增强剂系统（9：1； EI系统）显着增强了烷醇胺复合物通过大鼠皮肤膜的DA通量。在所检查的复合物中，双氯芬酸二乙醇胺对DA的渗透具有最大的增强作用。

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来源
《China-Japan Symposium on Pharmaceutical Preparations and Particulate Design; 20060515-17; Shenyang(CN)》|2006年|P.103-105|共3页
会议地点 Shenyang(CN)
作者
Liang Fang; Yu Liu; Zhonggui He;
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作者单位

Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Webhua Road, Shenhe, Shenyang, Liaoning 110016, China;

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会议组织
原文格式 PDF
正文语种 eng
中图分类制药化学工业;
关键词
diclofenac acid; DSC; FT-IR; diethanolamine; triethanolamine; N-(2-Hydroxyethyl) piperidine; complex; percutaneous absorption;

机译：双氯芬酸; DSC; FT-IR;二乙醇胺;三乙醇胺; N-（2-羟乙基）哌啶;络合物;经皮吸收;

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2. l-Menthol, Oleic Acid and Laurkidin in Absorption Enhancement of Free and Sodium Salt of Diclofenac Using Ethanol Treated Silicone Membrane as Model for Skin [J] . Yoshie Maitani, Kazue Shimada, Tsuneji Nagai Chemical and Pharmaceutical Bulletin . 1996,第2期

机译：乙醇处理的有机硅膜作为皮肤模型时，l-薄荷醇，油酸和月桂草素对双氯芬酸的游离盐和钠盐的吸收增强
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4. Enhanced in Vitro Percutaneous Absorption of Diclofenac acid by Complexation with Alkanolamines [C] . 2006中日制剂和粒子设计研讨会（China-Japan Symposium on Pharmaceutical Preparations and Particulate Design）论文集 . 2006

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5. Development and Evaluation of Dermatological Formulations Using Lower Level of Diclofenac Sodium with Enhanced in vitro Drug Release [D] . Kamath, Snigdha. 2020

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机译：双氯芬酸增强二十二碳甲酸诱导的肺癌细胞体外细胞凋亡
7. l-Menthol, Oleic Acid and Lauricidin in Absorption Enhancement of Free and Sodium Salt of Diclofenac Using Ethanol Treated Silicone Membrane as Model for Skin. [O] . Yoshie MAITANI, Kazue SHIMADA, Tsuneji NAGAI 1996

机译：使用乙醇处理的硅氧烷膜作为皮肤模型，L-MENTHOL，油酸和月桂酸钠免受双氯橡胶的游离和钠盐的吸收增强。

ENHANCED IN VITRO PECUTANEOUS ABSORPTION OF DICLOFENAC ACID BY COMPLEXATION WITH ALKANOLAMINES

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