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首页> 外文会议>China-Japan Symposium on Pharmaceutical Preparations and Particulate Design; 20060515-17; Shenyang(CN) >Preparation and characterization of water-soluble β-cyclodextrin polymer
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Preparation and characterization of water-soluble β-cyclodextrin polymer

机译：水溶性β-环糊精聚合物的制备与表征

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摘要

A novel modified cyclodextrin derivative, water-soluble β-cyclodextrin polymer (β-CDP) was prepared from β-cyclodextrin and epichlorohydrin through a one-step condensation polymerization. The results of FT-IR and ~(13)C-NMR showed that a water-soluble β-cyclodextrin polymer remained the cavity structure of β-CD, which make it provide with the capability of forming inclusion complexes with a variety of guest molecules. The characterization of β-CDP was investigated by XRD, and DSC, indicating that β-CDP was an amorphous compound stable to the heat. The solubility of β-CDP was increased up to 86.2 g/100ml, about 46.6 times higher than the value of β-CD (1.85 g/100ml). The hemolysis test showed the hemolytic activity of β-CDP was low in vitro, which could be used as a safety excipient for pharmaceutical formation. Due to the favorable properties of β-CDP, the application of β-CDP in poorly water-soluble drug delivery systems could be possible.
机译：由β-环糊精和环氧氯丙烷经一步缩合反应制得一种新型的改性环糊精衍生物水溶性β-环糊精聚合物（β-CDP）。 FT-IR和〜（13）C-NMR结果表明，水溶性β-环糊精聚合物保留了β-CD的空腔结构，使其具有与多种客体分子形成包合物的能力。 。用XRD和DSC研究了β-CDP的特征，表明β-CDP是对热稳定的无定形化合物。 β-CDP的溶解度增加至86.2 g / 100ml，是β-CD值（1.85 g / 100ml）的约46.6倍。溶血试验表明，β-CDP的体外溶血活性较低，可作为药物形成的安全辅料。由于β-CDP的良好特性，因此可能在水溶性差的药物递送系统中应用β-CDP。

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