Polymer micelles as gene and antitumor drug delivery carriers

机译：高分子胶束作为基因和抗肿瘤药物传递载体

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In recent years, polymeric micelles have emerged as a potential carrier in the various field of drug delivery system, with the characters of solubilization, lowly toxicity, long-circulation and tumor localization. Polymeric micelles are self-assembled by amphiphilic block or grafted copolymers, and show a structure composed of hydrophobic segments as the internal core and hydrophilic segments as a surrounding corona in aqueous medium, which are suit to be carriers for drugs with adverse properties. The hydrophobic core serves as a reservoir for hydrophobic drugs, whereas the hydrophilic shell with cationic property could complex with macromolecular drug by ionic interaction.

机译：近年来，高分子胶束已经成为药物递送系统各个领域中潜在的载体，具有增溶，低毒性，长循环和肿瘤定位等特点。高分子胶束是由两亲性嵌段或接枝共聚物自组装而成，在水性介质中显示出由疏水链段作为内芯和亲水链段作为周围电晕组成的结构，适合用作具有不良性质的药物的载体。疏水核充当疏水药物的储存库，而具有阳离子性质的亲水壳可通过离子相互作用与大分子药物络合。

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来源
《China-Japan Symposium on Pharmaceutical Preparations and Particulate Design; 20060515-17; Shenyang(CN)》|2006年|P.46-47|共2页
会议地点 Shenyang(CN)
作者
Fu-Qiang Hu; Meng-Dan Zhao; Hong Yuan; Yong-Zhong Du;
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作者单位

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, P.R. China;

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原文格式 PDF
正文语种 eng
中图分类制药化学工业;
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1. Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property:Tumor Permeability,Controlled Subcellular Drug Distribution,and Enhanced in Vivo Antitumor Efficacy [J] . Kevin J.Hamblett, Oliver W.Press, Damon l.Meyer, Bioconjugate Chemistry . 2005,第1期

机译：具有细胞内pH触发药物释放特性的聚合胶束药物载体的制备和生物学表征：肿瘤通透性，可控的亚细胞药物分布和增强的体内抗肿瘤功效
2. Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property:Tumor Permeability,Controlled Subcellular Drug Distribution,and Enhanced in Vivo Antitumor Efficacy [J] . Younsoo Bae, Nobuhiro Nishiyama, Shigeto Fukushima, Bioconjugate Chemistry . 2005,第1期

机译：具有细胞内pH-触发药物释放性的聚合物胶束药物载体的制备和生物学特征：肿瘤渗透性，受控亚细胞药物分布，增强体内抗肿瘤功效
3. Improving the carrier stability and drug loading of unimolecular micelle-based nanotherapeutics for acid-activated drug delivery and enhanced antitumor therapy [J] . Shi Xiaoxiao, Bai Shuang, Yang Cangjie, Journal of Materials Chemistry, B. materials for biology and medicine . 2018,第35期

机译：提高酸活性药物递送的单模胶束纳米治疗剂的载体稳定性和药物负载，增强抗肿瘤疗法
4. Polymer micelles as gene and antitumor drug delivery carriers [C] . Fu-Qiang Hu, Meng-Dan Zhao, Hong Yuan, China-Japan Symposium on Pharmaceutical Preparations and Particulate Design . 2006

机译：聚合物胶束作为基因和抗肿瘤药物递送载体
5. Stable polymer micelle systems as anti-cancer drug delivery carriers. [D] . Zeng, Yi. 2005

机译：稳定的聚合物胶束系统作为抗癌药物输送载体。
6. A novel pH-sensitive carrier for the delivery of antitumor drugs: histidine-modified auricularia auricular polysaccharide nano-micelles [O] . Yingying Wang, Pingfei Li, Fen Chen, -1

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7. A novel pH-sensitive carrier for the delivery of antitumor drugs: histidine-modified auricularia auricular polysaccharide nano-micelles [O] . Yingying Wang, Pingfei Li, Fen Chen, 2017

机译：用于递送抗肿瘤药物的新型pH敏感载体：组氨酸改性的Auricularia耳廓多糖纳米胶束
8. Multimodality CT/SPECT Evaluation of Micelle Drug Carriers for Treatment of Breast Tumors [R] . Blanco, E., Weinberg, B. D., Gao, J. 2008

机译：胶束药物载体治疗乳腺肿瘤的多模态CT / spECT评价

Polymer micelles as gene and antitumor drug delivery carriers

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