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首页> 外文会议>Clinical and biomedical spectroscopy and imaging IV >Non-contact high resolution Bessel beam probe for diagnostic imaging of cornea and trabecular meshwork region in eye
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Non-contact high resolution Bessel beam probe for diagnostic imaging of cornea and trabecular meshwork region in eye

机译：非接触式高分辨率贝塞尔光束探头，用于眼角膜和小梁网区域的诊断成像

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摘要

Primary angle closure glaucoma is a major form of disease that causes blindness in Asia and worldwide. In glaucoma, irregularities in the ocular aqueous outflow system cause an elevation in intraocular pressure (IOP) with subsequent death of retinal ganglion cells, resulting in loss of vision. High resolution visualization of the iridocorneal angle region has great diagnostic value in understanding the disease condition which enables monitoring of surgical interventions that decrease IOP. None of the current diagnostic techniques such as goniophotography, ultrasound biomicroscopy (UBM), anterior segment optical coherence tomography (AS-OCT) and RetCam™ can image with molecular specificity and required spatial resolution that can delineate the trabecular meshwork structures. This paper in this context proposes new concepts and methodology using Bessel beams based illumination and imaging for such diagnostic ocular imaging applications. The salient features using Bessel beams instead of the conventional Gaussian beam, and the optimization challenges in configuring the probe system will be illustrated with porcine eye samples.
机译：原发性闭角型青光眼是导致亚洲和世界范围内失明的主要疾病。在青光眼中，眼房水流出系统的不规则引起眼内压（IOP）升高，继而导致视网膜神经节细胞死亡，从而导致视力下降。虹膜角膜角区域的高分辨率可视化在了解疾病状况方面具有很大的诊断价值，从而可以监测降低IOP的外科手术。当前的诊断技术，例如断层摄影，超声生物显微镜（UBM），前节光学相干断层扫描（AS-OCT）和RetCam™均无法以分子特异性和所需的空间分辨率成像，从而可以描绘出小梁网结构。在这种情况下，本文针对此类诊断眼成像应用，提出了使用基于贝塞尔光束的照明和成像技术的新概念和新方法。使用贝塞尔光束而不是传统的高斯光束的显着特征，以及猪眼样本将说明配置探头系统时的优化挑战。

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  • 来源
  • 会议地点 Munich(DE)
  • 作者

    V M Murukeshan; Hong Xun Jie Jesmond; V K Shinoj; M Baskaran; Aung Tin;

  • 作者单位

    Center for Optical and Laser Engineering, School of Mechanical and Aerospace Engineering, 50 Nanyang Avenue, Singapore - 630798;

    Center for Optical and Laser Engineering, School of Mechanical and Aerospace Engineering, 50 Nanyang Avenue, Singapore - 630798;

    Center for Optical and Laser Engineering, School of Mechanical and Aerospace Engineering, 50 Nanyang Avenue, Singapore - 630798;

    Singapore Eye Research Institute (SERI) Singapore National Eye Center (SNEC), 11 Third Hospital Avenue, Singapore - 168751;

    Singapore Eye Research Institute (SERI) Singapore National Eye Center (SNEC), 11 Third Hospital Avenue, Singapore - 168751,Yong Loo Lin School of Medicine, National University of Singapore, Singapore;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Angle-closure glaucoma; trabecular meshwork; Bessel beam; Gaussian beam;

    机译：闭角型青光眼；小梁网贝塞尔光束高斯光束;

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