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Biomedical tools based on magnetic nanoparticles

机译：基于磁性纳米粒子的生物医学工具

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摘要

Magnetic and superparamagnetic colloids represent a versatile platform for the design of functional nanostructures which may act as effective tools for biomedicine, being active in cancer therapy, tissue imaging and magnetic separation. The structural, morphological and hence magnetic features of the magnetic nanoparticles must be tuned for optimal perfomance in a given application. In this work, iron oxide nanocrystals have been prepared as prospective heat mediators in magnetic fluid hyperthermia therapy. A procedure based on the partial oxidation of iron (Ⅱ) precursors in water based media has been adopted and the synthesis outcome has been investigated by X-Ray diffraction and Transmission electron microscopy. It was found that by adjusting the synthetic parameters (mainly the oxidation rate) magnetic iron oxide nanocrystals with cubic and cuboctahedral shape and average size 50 nm were obtained. The nanocrystals were tested as hyperthermic mediators through Specific Absorption Rate (SAR) measurements. The samples act as heat mediators, being able to increase the temperature from physiological temperature to the temperatures used for magnetic hyperthermia by short exposure to an alternative magnetic field and exhibit a reproducible temperature kinetic behavior.
机译：磁性和超顺磁性胶体代表了功能性纳米结构设计的通用平台，可以充当生物医学的有效工具，在癌症治疗，组织成像和磁分离中发挥作用。在给定的应用中，必须调整磁性纳米粒子的结构，形态和磁性特征，以实现最佳性能。在这项工作中，已经制备了氧化铁纳米晶体作为磁流体热疗中的预期热介质。采用了基于铁（Ⅱ）前体在水介质中部分氧化的方法，并通过X射线衍射和透射电子显微镜研究了合成结果。发现通过调节合成参数（主要是氧化速率），获得了具有立方和立方八面体形状且平均尺寸为50nm的磁性氧化铁纳米晶体。纳米晶体通过比吸收率（SAR）测量作为高温介质。样品充当热介质，能够通过短时间暴露于替代磁场将温度从生理温度升高到用于磁热疗的温度，并表现出可再现的温度动力学行为。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Anna R. Saba; Paula M. Castillo; Elvira Fantechi; Claudio Sangregorio; Alessandro Lascialfari; Andrea Sbarbati; Alberto Casu; Andrea Falqui; Maria F. Casula;

  • 作者单位

    INSTM and Dipartimento di Scienze Chimiche e Geologiche, Universita di Cagliari, I-09042 Monserrato (Ca), ITALY,INSTM and Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie , Universita di Verona, I-37134 Verona, ITALY;

    INSTM and Dipartimento di Scienze Chimiche e Geologiche, Universita di Cagliari, I-09042 Monserrato (Ca), ITALY;

    INSTM and Department of Chemistry 'U. Schiff', Universita di Firenze, I-50019 Sesto Fiorentino (Fi) ITALY;

    CNR-ISTM Milano and INSTM via C. Golgi 19, I-20133 Milano, ITALY;

    CNR and Department of Physics, Universita di Milano, I-20134 Milano, ITALY;

    INSTM and Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie , Universita di Verona, I-37134 Verona, ITALY;

    Nanochemistry, Istituto Italiano di Tecnologia, I.I.T. Via Morego 30, 16163 Genova, ITALY;

    INSTM and Dipartimento di Scienze Chimiche e Geologiche, Universita di Cagliari, I-09042 Monserrato (Ca), ITALY,Nanochemistry, Istituto Italiano di Tecnologia, I.I.T. Via Morego 30, 16163 Genova, ITALY;

    INSTM and Dipartimento di Scienze Chimiche e Geologiche, Universita di Cagliari, I-09042 Monserrato (Ca), ITALY;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    iron oxide; hyperthermia; ferrofluids;

    机译：氧化铁;热疗;铁磁流体;

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