Recent development of dihydrolipoic acid appended ligands for robust and biocompatible quantum dots

机译：二氢硫辛酸附加配体用于稳健和生物相容性量子点的最新进展

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Biocompatible nanoparticles have recently attracted significant attention due to increasing interest in their use for biological sensing, cellular labeling and in vivo imaging. Semiconductor quantum dots (QDs) with good colloidal stability as well as small hydrodynamic sizes are particularly useful within these applications. We have developed a series of dihydrolipoic acid (DHLA) based surface ligands to enhance the colloidal stability and biocompatibility of water soluble QDs. Modification of DHLA with poly(ethylene glycol) derivatives provided the QDs with extended colloidal stability over a wide pH range and under high salt concentrations, which contrasts with the limited colloidal stability provided by DHLA alone. Functionalization of the PEG termini enabled one to have easy access to the QD surface and construct a variety of stable QD-biomolecules conjugates. A series of DHLA-based compact ligands with zwitterionic character has also been explored to develop compact sized QDs without sacrificing the colloidal stability. Despite their smaller sizes than the PEG analogs, the QDs coated with the zwitterionic ligands still have excellent colloidal stability and minimize nonspecific interactions in biological environments. Recent studies of thiol-based multidentate ligands and ligand exchange methods further improved the colloidal stability and fluorescence quantum yields.

机译：由于对生物相容性纳米粒子用于生物传感，细胞标记和体内成像的兴趣日益浓厚，近来引起了广泛的关注。具有良好的胶体稳定性以及较小的流体动力学尺寸的半导体量子点（QD）在这些应用中特别有用。我们已经开发了一系列基于二氢硫辛酸（DHLA）的表面配体，以增强水溶性QD的胶体稳定性和生物相容性。用聚乙二醇衍生物对DHLA进行修饰为QD在宽pH范围和高盐浓度下提供了扩展的胶体稳定性，这与DHLA单独提供的有限的胶体稳定性形成了鲜明的对比。 PEG末端的功能化使人们可以轻松访问QD表面并构建各种稳定的QD生物分子偶联物。还研究了一系列具有两性离子特性的基于DHLA的紧凑型配体，以开发紧凑尺寸的量子点，而又不牺牲胶体稳定性。尽管它们的大小比PEG类似物小，但两性离子配体包被的QD仍具有出色的胶体稳定性，并使生物环境中的非特异性相互作用最小化。基于硫醇的多齿配体和配体交换方法的最新研究进一步提高了胶体稳定性和荧光量子产率。

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《Colloidal nanoparticles for biomedical applications VIII》|2013年|859515.1-859515.9|共9页
会议地点 San Francisco CA(US)
作者
Kimihiro Susumu; Eunkeu Oh; Michael H. Stewart; James B. Delehanty; Kelly Boeneman Gemmill; Vaibhav Jain; Alan L. Huston; Igor L. Medintz;
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作者单位

Optical Sciences Division, Naval Research Laboratory, Washington, DC 20375,Sotera Defense Solutions, Annapolis Junction, MD 20701;

Optical Sciences Division, Naval Research Laboratory, Washington, DC 20375,Sotera Defense Solutions, Annapolis Junction, MD 20701;

Optical Sciences Division, Naval Research Laboratory, Washington, DC 20375;

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375;

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375;

Optical Sciences Division, Naval Research Laboratory, Washington, DC 20375;

Optical Sciences Division, Naval Research Laboratory, Washington, DC 20375;

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375;

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原文格式 PDF
正文语种 eng
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关键词
quantum dot; ligand exchange; dihydrolipoic acid; multidentate; poly(ethylene glycol); zwitterion;

机译：量子点配体交换二氢硫辛酸多齿聚乙二醇）;两性离子;

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专利

1. Multifunctional ligands based on dihydrolipoic acid and polyethylene glycol to promote biocompatibility of quantum dots [J] . Kimihiro Susumu, Bing C Mei, Hedi Mattoussil Nature protocols erecipes for researchers . 2009,第3期

机译：基于二氢硫辛酸和聚乙二醇的多功能配体，可促进量子点的生物相容性
2. A New Family of Pyridine-Appended Multidentate Polymers As Hydrophilic Surface Ligands for Preparing Stable Biocompatible Quantum Dots [J] . Kimihiro Susumu, Eunkeu Oh, James B. Delehanty Chemistry of Materials: A Publication of the American Chemistry Society . 2014,第18期

机译：吡啶附加的多齿聚合物作为亲水性表面配体的新家族，用于制备稳定的生物相容性量子点
3. A robust ligand exchange approach for preparing hydrophilic, biocompatible photoluminescent quantum dots [J] . Sujuan Wang, Changhua Zhou, Hang Yuan, Materials Research Bulletin . 2013,第8期

机译：一种强大的配体交换方法，用于制备亲水性，生物相容性的光致发光量子点
4. Recent development of dihydrolipoic acid appended ligands for robust and biocompatible quantum dots [C] . Kimihiro Susumu, Eunkeu Oh, Michael H. Stewart, SPIE Conference on Colloidal Nanocrystals for Biomedical Applications . 2013

机译：最近的二氢硅酸己酸和生物相容性量子点的配体附加配体
5. Attaching CdSe Quantum Dots to TiO2 Using Ligands with Phosphonic and Hydroxamic Acid Anchoring Groups: A Study of Persistence and Electron Transfer [D] . Schmidt, Zachery Alexander. 2020

机译：使用具有膦和羟肟酸锚定组的配体将CDSE量子点连接到TiO 2：持久性和电子转移的研究
6. Overview of Stabilizing Ligands for Biocompatible Quantum Dot Nanocrystals [O] . Yanjie Zhang, Aaron Clapp 2011

机译：生物相容性量子点纳米晶体的稳定配体概述
7. Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand [O] . Liu, Wenhao, Greytak, Andrew B., Lee, Jungmin, 2014

机译：通过RAFT介导的咪唑基无规共聚物配体的合成实现紧凑的生物相容性量子点

Recent development of dihydrolipoic acid appended ligands for robust and biocompatible quantum dots

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