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Highly Efficient Multifunctional MnSe/ZnSeS Quantum Dots for Biomedical Applications

机译:用于生物医学应用的高效多功能MnSe / ZnSeS量子点

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Colloidal quantum dots (QDs) are of interest for a variety of biomedical applications, including bioimaging, drug targeting, and photodynamic therapy. However, a significant limitation is that highly efficient photoluminescent QDs available commercially contain cadmium. Recent research has focused on cadmium-free QDs, which are anticipated to exhibit significantly lower cytotoxicity. Previous work has focused on InP and ZnO as alternative semiconductor materials for QDs. However, these nanoparticles have been shown to be cytotoxic. Recently, we have synthesized high quantum efficiency (exceeding 90%), color tunable MnSe/ZnSeS nanoparticles, as potentially attractive QDs for biomedical applications. Additionally, the manganese imparts magnetic properties on the QDs, which are important for magnetic field-guided transport, hyperthermia, and potentially magnetic resonance imaging (MRI). The QDs can be further biofunctionalized via conjugation to a ligand or a biomarker of disease, allowing combination of drug delivery with visual verification and colocalization due to the color tunability of the QDs.
机译:胶体量子点(QD)对于包括生物成像,药物靶向和光动力疗法在内的各种生物医学应用都很重要。但是,一个明显的局限性是,可商购的高效光致发光QD包含镉。最近的研究集中在无镉的量子点,预计将显示出明显更低的细胞毒性。先前的工作集中在InP和ZnO作为QD的替代半导体材料上。但是,这些纳米颗粒已经显示出细胞毒性。最近,我们合成了高量子效率(超过90%),颜色可调的MnSe / ZnSeS纳米颗粒,作为对生物医学应用具有潜在吸引力的QD。此外,锰在量子点上赋予了磁性,这对于磁场引导的传输,热疗以及潜在的磁共振成像(MRI)至关重要。可以通过与疾病的配体或生物标记物偶联而使QD进一步生物功能化,由于QD的颜色可调性,可以将药物递送与视觉验证和共定位结合起来。

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