• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Colloidal nanoparticles for biomedical applications VIII >Colloidal gold nanorings for improved photodynamic therapy through field-enhanced generation of reactive oxygen species
【24h】

Colloidal gold nanorings for improved photodynamic therapy through field-enhanced generation of reactive oxygen species

机译：胶体金纳米环通过增强场中活性氧的产生来改善光动力疗法

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Au nanostructures that exhibit strong localized surface plasmon resonance (SPR) have excellent potential for photo-medicine, among a host of other applications. Here, we report the synthesis and use of colloidal gold nanorings (GNRs) with potential for enhanced photodynamic therapy of cancer. The GNRs were fabricated via galvanic replacement reaction of sacrificial Co nanoparticles in gold salt solution with low molecular weight (Mw = 2,500) poly(vinylpyrrolidone) (PVP) as a stabilizing agent. The size and the opening of the GNRs were controlled by the size of the starting Co particles and the concentration of the gold salt. UV-Vis absorption measurements indicated the tunability of the SPR of the GNRs from 560 nm to 780 ran. MTT assay showed that GNRs were non-toxic and biocompatible when incubated with breast cancer cells as well as the healthy counterpart cells. GNRs conjugated with 5-aminolevulinic acid (5-ALA) photosensitizer precursor led to elevated formation of reactive oxygen species and improved efficacy of photodynamic therapy of breast cancer cells under light irradiation compared to 5-ALA alone. These results can be attributed to significantly enhance localized electromagnetic field of the GNRs.
机译：在许多其他应用中，展现出强局部表面等离子体共振（SPR）的金纳米结构在光医学领域具有极好的潜力。在这里，我们报告了胶体金纳米环（GNRs）的合成和使用，具有增强癌症光动力疗法的潜力。 GNR是通过牺牲性Co纳米粒子在金盐溶液中进行电流置换反应制成的，该盐溶液以低分子量（Mw = 2,500）聚（乙烯基吡咯烷酮）（PVP）为稳定剂。 GNR的大小和开度由起始Co颗粒的大小和金盐的浓度控制。紫外-可见吸收测量表明，GNR的SPR在560 nm至780 nm范围内可调。 MTT分析表明，当与乳腺癌细胞以及健康的对应细胞孵育时，GNRs无毒且具有生物相容性。与单独的5-ALA相比，与5-氨基乙酰丙酸（5-ALA）光敏剂前体缀合的GNR导致活性氧种类的形成增加，并改善了光照射下乳腺癌细胞的光动力治疗功效。这些结果可归因于显着增强了GNR的局部电磁场。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Yue Hu; Yamin Yang; Hongjun Wang; Henry Du;

  • 作者单位

    Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ 07030, USA;

    Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA;

    Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA;

    Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ 07030, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Gold; Colloidal; Nanoring; Photodynamic Therapy;

    机译：金;胶体;纳米环光动力疗法;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号