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首页> 外文会议>Colloidal nanoparticles for biomedical applications VIII >The biocompatibility of nanosized materials: Intracellular nanoparticle stability and effects on toxicity and particle functionality
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The biocompatibility of nanosized materials: Intracellular nanoparticle stability and effects on toxicity and particle functionality

机译：纳米材料的生物相容性：细胞内纳米颗粒的稳定性以及对毒性和颗粒功能的影响

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摘要

The present work describes the use of a recently established multiparametric methodology to study nanomaterial toxicity. Using optimized methods, including proliferation-restricted cell types and endosomal buffer systems, the effect of different types of nanomaterials on cultured cells were studied, focusing in particular on intracellular particle degradation. Gold particles were quite resistant, whereas iron oxide degraded, with loss of magnetic resonance contrast, but little toxicity associated. Quantum dots degraded more slowly, decreasing both fluorescence quantum yield and cell viability over long-time periods. The multiparametric methodology is shown to be an efficient screening strategy, allowing easy comparison of results obtained for different nanomaterials and hereby helping to optimize nanoparticle design with improved safety.
机译：本工作描述了使用最近建立的多参数方法来研究纳米材料的毒性。使用包括增殖受限细胞类型和内体缓冲液系统在内的优化方法，研究了不同类型的纳米材料对培养细胞的影响，尤其着眼于细胞内颗粒降解。金颗粒具有很强的抵抗力，而氧化铁降解，具有磁共振对比度的损失，但几乎没有毒性。量子点降解速度较慢，长时间内荧光量子产率和细胞活力均下降。多参数方法论被证明是一种有效的筛选策略，可以轻松比较从不同纳米材料获得的结果，从而有助于以提高的安全性优化纳米颗粒的设计。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Stefaan J. Soenen; Stefaan C. De Smedt; Kevin Braeckmans;

  • 作者单位

    Lab of General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B9000 Gent, Belgium,Center of Nano- and Biophotonics, Department of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B9000 Gent, Belgium;

    Lab of General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B9000 Gent, Belgium;

    Lab of General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B9000 Gent, Belgium,Center of Nano- and Biophotonics, Department of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B9000 Gent, Belgium;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    nanotoxicity; nanoparticles; quantum dots; gold nanoparticles; iron oxide nanoparticles; silica nanoparticles;

    机译：纳米毒性纳米粒子量子点;金纳米粒子氧化铁纳米粒子；二氧化硅纳米粒子;

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