Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension

机译：生物分子对悬浮液中胶体纳米粒子电动动力学的影响

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Electric fields can induce various types of motion in liquid suspensions of colloidal nanoparticles. These electrokinetic phenomena depend on the parameters of the electric field (frequency, amplitude, 3D topology), the particles (size, shape, composition) and the suspending liquid (polarizability, ionic strength, pH). In particular, the dielectrophoretic force on submicron colloidal particles is dependent on the properties of the electric double layer (the "ion cloud") around these particles. This dependence provides a mechanism for detecting and quantifying interactions between biomolecules and these nanoparticles, which can be combined with optical and spectroscopic measurements. Here, we report on functionalized plasmonic nanoparticles that are tracked inside microfluidic systems by dark-field video-microscopy. A high-gradient AC electric field is set up using transparent micro-electrodes. Electrohydrodynamic motion of the entire fluid and dielectrophoretic trapping of individual particles can be analyzed quantitatively by numerical methods. By switching the electric field synchronously with the video acquisition, the effect of biomolecules on the electrokinetic trapping can be quantified. The electromicrofluidic devices allow also for rapid measurement of diffusion coefficients.

机译：电场可以在胶态纳米颗粒的液体悬浮液中引发各种类型的运动。这些电动现象取决于电场（频率，幅度，3D拓扑），粒子（大小，形状，组成）和悬浮液体（极化率，离子强度，pH）的参数。特别地，对亚微米胶体颗粒的介电泳力取决于这些颗粒周围的双电层（“离子云”）的性质。这种依赖性为检测和定量生物分子与这些纳米颗粒之间的相互作用提供了一种机制，可以与光学和光谱测量结合使用。在这里，我们报道了通过暗场视频显微镜在微流体系统内部跟踪的功能化等离子体纳米颗粒。使用透明微电极可建立高梯度交流电场。可以通过数值方法定量分析整个流体的电流体动力学运动和单个颗粒的介电泳捕获。通过与视频采集同步切换电场，可以量化生物分子对电动捕获的影响。电微流体装置还允许快速测量扩散系数。

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来源
《Colloidal nanoparticles for biomedical applications XII》|2017年|100780T.1-100780T.11|共11页
会议地点 San Francisco(US)
作者
C. Midelet; J.-Y. Lin; S. Tsang; C.-l. Sun; J. Midelet; A. G. Kanaras; B. Le Pioufle; O. Francais; M. H. V. Werts;
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作者单位

SATIE (UMR 8029), Ecole normale superieure de Rennes, CNRS, Campus de Ker Lann, F-35170 Bruz, France;

Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan;

Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan;

Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan;

Department of Physics and Astronomy, University of Southampton, Southampton, England;

Department of Physics and Astronomy, University of Southampton, Southampton, England;

SATIE (UMR 8029), Ecole normale superieure Paris-Saclay, F-94235 Cachan, France F-94235 Cachan, France;

ESIEE-Paris, ESYCOM, University Paris-Est, F-93160 Noisy Le Grand, France;

SATIE (UMR 8029), Ecole normale superieure de Rennes, CNRS, Campus de Ker Lann, F-35170 Bruz, France;

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原文格式 PDF
正文语种 eng
中图分类
关键词
electrokinetics; dielectrophoresis; microfluidics; resonant light scattering; video microscopy; colloidal suspensions; nanoparticles; plasmonic nanoparticles;

机译：电动学介电泳微流体共振光散射；电子显微镜胶体悬浮液；纳米粒子等离子体纳米颗粒;

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专利

1. Ion size effects on the dielectric and electrokinetic properties in aqueous colloidal suspensions [J] . Lopez-Garcia J. J., Horno J., Grosse C. Current opinion in colloid & interface science . 2016,第Auga期

机译：离子尺寸对水性胶体悬浮液介电和电动特性的影响
2. Characterization and magnetic properties of nickel and nickel-iron nanoparticle colloidal suspensions in imidazolium-based ionic liquids prepared by magnetron sputtering [J] . Cigan A., Lobotka P., Dvurecenskij A., Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics . 2018,第期

机译：磁氮杂基离子液体中镍和镍 - 铁纳米粒子胶体悬浮液的表征和磁性特性
3. Creating sub-50 nm nanofluidic junctions in a PDMS microchip via self-assembly process of colloidal silica beads for electrokinetic concentration of biomolecules [J] . Syed A., Mangano L., Mao P., Lab on a chip . 2014,第23期

机译：通过胶体二氧化硅珠的自组装过程在PDMS微芯片中创建亚50 nm纳米流体连接，以电动浓缩生物分子
4. Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension [C] . C. Midelet, J.-Y. Lin, S. Tsang, Conference on colloidal nanoparticles for biomedical applications XII . 2017

机译：生物分子对液体悬浮液中胶体纳米粒子电动力学的影响
5. Transport of nanoparticles and reacting biomolecules in micro- and nanofluidic electrokinetic systems. [D] . Wynne, Thomas Mikio. 2013

机译：纳米和微流体电动系统中纳米颗粒和生物分子的反应运输。
6. Creating Sub-50 nm Nanofluidic Junctions in PDMS Microchip via Self-Assembly Process of Colloidal Silica Beads for Electrokinetic Concentration of Biomolecules [O] . A. Syed, L. Mangano, P. Mao, -1

机译：通过硅胶分子的自组装过程在PDMS芯片中创建亚50 nm纳米流体结用于电动浓缩生物分子。
7. Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension [O] . Midelet, Clyde, Lin, J.-Y., Tsang, Sung, 2017

机译：生物分子对悬浮液中胶体纳米粒子电动动力学的影响

Effects of biomolecules on the electrokinetics of colloidal nanoparticles in liquid suspension

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