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Radiation sensitivity enhancement in cells using high-Z nanoparticles

机译:使用高Z纳米粒子增强细胞的辐射敏感性

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摘要

Cerium-doped lanthanum fluoride colloidal nanocrystals offer a way to improve radiation therapy through the enhanced absorption of high-energy photons. Lanthanum fluoride nanocrystals doped with 10% cerium and capped with oleic acid were synthesized in anhydrous methanol as platelets 3-6 nm in diameter and 1-3 nm thick. The nanocrystals were characterized by transmission electron microscopy and photoluminescence spectroscopy. Previously synthesized lanthanum fluoride nanocrystals doped with 10% cerium and capped with hydroxyl were used in radiation dose enhancement experiments that involved an incoming gamma flux from a ~(137)Cs source and a FOX assay to measure absorbed energy. Possibility for lanthanide ions to be released into solution under gamma irradiation and to interfere with the assay was shown after the results were compared with the outcome of a similar previous experiment with the Fricke dosimeter solution. Finally, increased cell mortality of S. cerevisiae under gamma irradiation was observed in the presence of hydroxyl-capped lanthanum fluoride nanocrystals in the solution.
机译:铈掺杂的氟化镧胶体纳米晶体提供了一种通过增强高能光子吸收来改善放射治疗的方法。在无水甲醇中合成了直径为3-6 nm,厚度为1-3 nm的氟化镧纳米晶体,掺杂了10%的铈并用油酸封端。通过透射电子显微镜和光致发光光谱法表征了纳米晶体。先前合成的掺有10%铈和羟基封端的氟化镧纳米晶体被用于辐射剂量增强实验,该实验涉及从〜(137)Cs源引入的伽马通量和FOX测定以测量吸收的能量。将结果与之前使用Fricke剂量计溶液进行的类似实验的结果进行比较后,表明了镧系元素离子在伽马射线辐照下会释放到溶液中并干扰测定的可能性。最后,在溶液中存在羟基封端的氟化镧纳米晶体的情况下,观察到在γ射线照射下酿酒酵母的细胞死亡率增加。

著录项

  • 来源
    《Colloidal quantum dots for biomedical applications V》|2010年|P.75750Z.1-75750Z.10|共10页
  • 会议地点 San Francisco CA(US)
  • 作者单位

    Center for High Technology Materials, University of New Mexico, 1313 Goddard SE,Albuquerque, New Mexico 87106-4343;

    Center for High Technology Materials, University of New Mexico, 1313 Goddard SE,Albuquerque, New Mexico 87106-4343;

    Center for High Technology Materials, University of New Mexico, 1313 Goddard SE,Albuquerque, New Mexico 87106-4343;

    Center for High Technology Materials, University of New Mexico, 1313 Goddard SE,Albuquerque, New Mexico 87106-4343;

    Center for High Technology Materials, University of New Mexico, 1313 Goddard SE,Albuquerque, New Mexico 87106-4343;

    Center for High Technology Materials, University of New Mexico, 1313 Goddard SE,Albuquerque, New Mexico 87106-4343;

    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131;

    Center for High Technology Materi;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    colloidal nanoparticles scintillation radiation damage;

    机译:胶体纳米粒子闪烁辐射损伤;

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