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An Evolutionary Study of the Human Papillomavirus Genomes

机译：人类乳头瘤病毒基因组的进化研究。

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In this article, we undertake a study of the evolution of Human Papillomaviruses (HPV), whose potential to cause cervical cancer is well known. First, we found that the existing HPV groups are monophyletic and that the high-risk carcinogenicity taxa are usually clustered together. Then, we present a new algorithm for analyzing the information content of multiple sequence alignments in relation to epidemiologic carcinogenicity data to identify regions that would warrant additional experimental analyses. The new algorithm is based on a sliding window procedure looking for genomic regions being responsible for disease. Examination of the genomes of 83 HPVs allowed us to identify specific regions that might be influenced by insertions, deletions, or simply by mutations, and that may be of interest for further analyses.

机译：在本文中，我们对人乳头瘤病毒（HPV）的进化进行了研究，其可能引起宫颈癌。首先，我们发现现有的HPV组是单系的，并且高风险致癌分类群通常聚集在一起。然后，我们提出了一种新算法，用于分析与流行病学致癌性数据相关的多个序列比对的信息内容，以识别需要进行额外实验分析的区域。新算法基于滑动窗口程序，寻找导致疾病的基因组区域。对83株HPV的基因组进行的检查使我们能够鉴定出可能受插入，缺失或仅受突变影响的特定区域，这些区域可能对进一步的分析感兴趣。

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来源
《Comparative Genomics》|2008年|128-142|共15页
会议地点 Paris(FR);Paris(FR)
作者
Dunarel Badescu; Abdoulaye Banire Diallo; Mathieu Blanchette; Vladimir Makarenkov;
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作者单位

Departement d'informatique, Universite du Quebec a Montreal, C.P. 8888,Succursale Centre-Ville, Montreal (Quebec), H3C 3P8, Canada;

Departement d'informatique, Universite du Quebec a Montreal, C.P. 8888,Succursale Centre-Ville, Montreal (Quebec), H3C 3P8, Canada McGill Centre for Bioinformatics and School of Computer Science, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada;

McGill Centre for Bioinformatics and School of Computer Science, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada;

Departement d'informatique, Universite du Quebec a Montreal, C.P. 8888,Succursale Centre-Ville, Montreal (Quebec), H3C 3P8, Canada;

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原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
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1. Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women [J] . Feng Yang-chun, Wang Sen-yu, Zhang Yuan, Journal of immunology research. . 2020,第1期

机译：人类乳头瘤病毒DNA的基因组分析融入人类基因组及其对中国UYGUR宫颈癌女性PD-L1表达的影响
2. Human papillomavirus type 18 chimeras containing the L2/L1 capsid genes from evolutionarily diverse papillomavirus types generate infectious virus. [J] . Bowser BS, Chen HS, Conway MJ, Virus Research: An International Journal of Molecular and Cellular Virology . 2011,第1a2期

机译：包含来自进化上不同的乳头瘤病毒类型的L2 / L1衣壳基因的人乳头瘤病毒18型嵌合体会产生传染性病毒。
3. Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection [J] . Sally N. Adebamowo, Adebowale A. Adeyemo, Charles N. Rotimi, BMC Medical Genetics . 2020,第1期

机译：基因组 - 普遍存在和持续性颈椎高风险人乳头瘤病毒（HPV）感染的基因组
4. An Evolutionary Study of the Human Papillomavirus Genomes [C] . Dunarel Badescu, Abdoulaye Banire Diallo, Mathieu Blanchette, International Workshop on Comparative Genomics . 2008

机译：一种对人乳头瘤病毒基因组的进化研究
5. DNA replication and genome maintenance of human papillomavirus type 16 in mammalian cells. [D] . Pittayakhajonwut, Daraporn. 2010

机译：人类乳头瘤病毒16型在哺乳动物细胞中的DNA复制和基因组维护。
6. Evolutionary Dynamics of Variant Genomes of Human Papillomavirus Types 18 45 and 97 [O] . Zigui Chen, Rob DeSalle, Mark Schiffman, 2009

机译：人类乳头瘤病毒18、45和97型变异基因组的进化动力学。
7. Whole Genome Sequencing and Evolutionary Analysis of Human Papillomavirus Type 16 in Central China [O] . Sun, Min, Gao, Lei, Liu, Ying, 2012

机译：华中地区人乳头瘤病毒16型的全基因组测序和进化分析

An Evolutionary Study of the Human Papillomavirus Genomes

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