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首页> 外文会议>Complex Medical Engineering, 2009. CME >Effects of repetitive transcranial magnetic stimulation on ictogenesis in genetically epileptic EL mice
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Effects of repetitive transcranial magnetic stimulation on ictogenesis in genetically epileptic EL mice

机译：重复经颅磁刺激对遗传性癫痫EL小鼠信息发生的影响

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Genetically epileptic EL mice develop the ictogenesis if they receive tossing-up stimulation from 12 weeks old. We investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on the development of ictogenesis in EL mice. Female EL mice have received low (1Hz)- or high (10Hz)-frequency rTMS (100% of motor threshold, 300 pulses/day, once a week) from 8 to 19 weeks old. From 12 to 19 weeks, we evaluated the seizure frequency, seizure threshold and duration of seizures. Low-frequency rTMS decreased the frequency of seizure from 12 to 15 weeks. High-frequency rTMS also decreased the frequency of seizure from 15 to 19 weeks. Low and high-frequency rTMS didn't change the seizure threshold and durations of seizures. Our results suggest that rTMS has the potency to inhibit the development of ictogenesis, but the efficacy is varied according to the frequency of rTMS.
机译：如果遗传癫痫病的EL小鼠从12周龄开始受到刺激，它们就会发展成黑。我们调查了重复经颅磁刺激（rTMS）对EL小鼠信息发生发展的影响。雌性EL小鼠从8周到19周龄接受了低频（1Hz）或高频（10Hz）rTMS（运动阈值的100％，每天300次脉冲，每天一次）。从12到19周，我们评估了癫痫发作频率，癫痫发作阈值和癫痫发作持续时间。低频rTMS将癫痫发作频率从12周降低到15周。高频rTMS也将癫痫发作频率从15周降低到19周。低频和高频rTMS不会改变癫痫发作的阈值和发作时间。我们的结果表明，rTMS具有抑制致癌现象发展的潜能，但功效随rTMS的频率而变化。

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