Effect of Ca~(2+) on presynaptic facilitation

机译：Ca〜（2+）对突触前促进的影响

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We investigated and modeled the effect of Ca~(2+) on presynaptic facilitation. Facilitation of transmitter release from a presynaptic terminal is believed to arise from the local increase of Ca~(2+) concentration. We measured and simulated the effect of Ca~(2+) on facilitation at the lobster neuromuscular synapse. Facilitation was measured using quantal analysis of postsynaptic potentials recorded focally during trains of stimuli. We found a facilitation component, which was not affected by Ca~(2+) concentration. Transmitter release was simulated using a model of two pools of presynaptic vesicles available for release. The simulation reproduced quantitatively Ca~(2+)-dependent and Ca~(2+)-independent components of facilitation.

机译：我们调查并模拟了Ca〜（2+）对突触前促进的影响。认为从突触前末端释放递质的促进是由于Ca〜（2+）浓度的局部增加所致。我们测量并模拟了Ca〜（2+）对龙虾神经肌肉突触的促进作用。使用刺激过程中集中记录的突触后电位的定量分析来测量促进程度。我们发现促进成分不受Ca〜（2+）浓度的影响。使用两个可用于释放的突触前囊泡池的模型模拟变送器的释放。该模拟定量地再现了促进Ca〜（2+）和依赖Ca〜（2+）的成分。

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来源
《Computational Neuroscience Meeting (CNS'01) Jul, 2001 Monterey, California》|2001年|p.1-5|共5页
会议地点 Monterey CA(US);Monterey CA(US)
作者
Maria Bykhovskaia; Elena Polagaeva; John T. Hackett;
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作者单位

Health Sciences Center, Department of Molecular Physiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA;

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会议组织
原文格式 PDF
正文语种 eng
中图分类生理学;
关键词
intracellular Ca~(2+); synaptic transmission; neuromuscular junction; releasable pool of synaptic vesicles; neurosecretion;

机译：细胞内Ca〜（2+）;突触传递;神经肌肉接头;突触小泡可释放池;神经营养;

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2. Effect of Ca~2+ on presynaptic facilitation [J] . Maria Bykhovskaia, Elena Polagaeva, John T. Hackett Neurocomputing . 2002,第期

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Effect of Ca~(2+) on presynaptic facilitation

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