首页> 外文会议>Computational Neuroscience Meeting (CNS'01) Jul, 2001 Monterey, California >Modelling the influence of thalamo-cortical projections on prefrontal activity
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Modelling the influence of thalamo-cortical projections on prefrontal activity

机译:模拟丘脑皮质投射对额叶活动的影响

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Altered connections between the thalamus and the prefrontal cortex are often implicated in theories concerning the pathogenesis of schizophrenia. Using a model based on anatomically realistic connection patterns between thalamus and prefrontal cortex, we analyzed changes of prefrontal activity resulting from stimulation of the mediodorsal thalamus. Here we demonstrate that the specific influence of thalamo-cortical projections is smaller than the importance of intra-prefrontal connectivity in shaping prefrontal activity patterns. These results might be helpful in explaining experimentally observed hypo- and hyperactive states of prefrontal cortex in schizophrenic patients.
机译:丘脑和前额叶皮层之间的连接改变通常与精神分裂症的发病机理有关。使用基于丘脑和前额叶皮层之间的解剖学现实连接模式的模型,我们分析了由于刺激中腹丘脑而引起的前额叶活动的变化。在这里,我们证明了丘脑皮质投射的具体影响小于在塑造前额叶活动模式中前额叶内连接的重要性。这些结果可能有助于解释精神分裂症患者实验观察到的额叶皮层过低和过度活跃状态。

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