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Does a dendritic democracy need a ruler?

机译:树突民主制需要统治者吗?

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In hippocampal CA1 cells, distance-dependent synaptic scaling (Nat. Neurosci. 3 (2000) 895, J. Neurosci. 21 (2001) 9151) helps maintain a "dendritic democracy" (Curr. Biol. 11 (2001) R10) where distal and proximal synapses on average contribute equally to the cell's firing. A "dendritic ruler", for example a concentration gradient, might be necessary for synaptic scaling. Alternatively, synapses could "self-regulate" by gauging their distance from the soma using properties of backpropagating spikes. We show in a model CA1 cell (Neuron 37 (2003) 977) that the delay between a synchronous burst of simulated Schaffer collateral input and the arrival of backpropagating spikes at synapses predict the synapse's location and amplitude at the soma well, though the amplitude of the spikes do not. This suggests that a dendritic ruler is not required to scale synapses.
机译:在海马CA1细胞中,距离依赖性突触缩放(Nat。Neurosci。3(2000)895,J. Neurosci。21(2001)9151)帮助维持“树突民主”(Curr。Biol。11(2001)R10),其中平均而言,远端和近端突触对细胞的发射有同等作用。对于突触缩放,可能需要“树突尺”(例如浓度梯度)。备选地,突触可以通过反向传播尖峰的特性来衡量它们与躯体的距离,从而“自我调节”。我们在模型CA1单元(Neuron 37(2003)977)中显示,模拟Schaffer侧支输入的同步爆发与反向传播尖峰到达突触之间的延迟可以预测突触的位置和振幅,尽管其幅度在尖峰没有。这表明不需要树突尺来缩放突触。

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