Localization of activated Ca~(2+)/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation

机译：激活的Ca〜（2 +）/钙调蛋白依赖性蛋白激酶II在脊柱内的定位：建模和计算机模拟

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Ca~(2+)/calmodulin-dependent protein kinase II (CaMKII) plays a crucial role in the induction of long-term potentiation (LTP). One form of LTP expression is thought to be the phosphorylation of glutamate receptor channels by CaMKII. Thus the localization of activated CaMKII within a spine will affect the expression of LTP. The translocation of activated CaMKII to PSD was reported. Here we investigated the localization of activated CaMKII in a model dendritic spine, and found that the diffusion of calmodulin and calcineurin but not CaMKII contribute to the localization of activated CaMKII near PSD. This will offer an additional mechanism for the localization.

机译：Ca〜（2 +）/钙调蛋白依赖性蛋白激酶II（CaMKII）在诱导长时程增强（LTP）中起关键作用。 LTP表达的一种形式被认为是CaMKII使谷氨酸受体通道磷酸化。因此，激活的CaMKII在脊柱内的定位将影响LTP的表达。据报道，活化的CaMKII易位至PSD。在这里，我们调查了激活的CaMKII在模型树突棘中的定位，发现钙调蛋白和钙调神经磷酸酶的扩散而非CaMKII的扩散有助于PSD附近激活的CaMKII的定位。这将为本地化提供其他机制。

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来源
《Computational Neuroscience Meeting(CNS03); 20030705-09; Alicante(ES)》|2003年|P.443-448|共6页
会议地点 Alicante(ES)
作者
Kazuhisa Ichikawa;
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作者单位

Advanced Research Institute for Science and Technology, Waseda University, 3-4-1 Okubo, Shinjyukuku, Tokyo 169-8555, Japan;

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会议组织
原文格式 PDF
正文语种 eng
中图分类生理学;
关键词
synaptic plasticity; spine; CaMKII; calmodulin; localization;

机译：突触可塑性;脊柱; CaMKII;钙调蛋白;定位;
入库时间 2022-08-26 14:29:49

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1. Localization of activated Ca~(2+)/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation [J] . Kazuhisa Ichikawa Neurocomputing . 2004,第期

机译：激活的Ca〜（2 +）/钙调蛋白依赖性蛋白激酶II在脊柱内的定位：建模和计算机模拟
2. Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation. [J] . Liu J, Fukunaga K, Yamamoto H, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 1999,第19期

机译：Ca（2 +）/钙调蛋白依赖性蛋白激酶II和有丝分裂原激活的蛋白激酶激活在海马长期增强中的差异作用。
3. Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of [J] . Min DS, Cho NJ, Yoon SH, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2000,第1期

机译：磷脂酶C，蛋白激酶C，Ca（2 +）/钙调蛋白依赖性蛋白激酶II和酪氨酸磷酸化参与了卡巴胆碱诱导的表达仓鼠蕈毒碱乙酰胆碱受体的中国仓鼠卵巢细胞中的磷脂酶D活化。
4. Localization of activated Ca~(2+)/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation [C] . Kazuhisa Ichikawa Computational Neuroscience Meeting . 2004

机译：活化的Ca〜（2 +）/钙调蛋白依赖性蛋白激酶II的定位在脊柱内：建模和计算机仿真
5. The importance of subcellular localization of calcium(2+)/calmodulin-dependent protein kinase II in neuronal differentiation. [D] . Kutcher, Louis Wm., III. 2003

机译：钙（2 +）/钙调蛋白依赖性蛋白激酶II亚细胞定位在神经元分化中的重要性。
6. Role of Ca2+/calmodulin-dependent protein kinase II in dendritic spine remodeling during epileptiform activity in vitro [O] . Xiang-ming Zha, Michael E. Dailey, Steven H. Green -1

机译：在体外癫痫活性期间Ca2 + /钙调蛋白依赖性蛋白激酶II在树突脊柱重塑中的作用
7. Activation of type II calcium/calmodulin-dependent protein kinase by Ca^(2+)/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain [O] . Patton Bruce L., Miller Stephen G., Kennedy Mary B. 1990

机译：Ca ^（2 +）/钙调蛋白对II型钙/钙调蛋白依赖性蛋白激酶的激活被钙调蛋白结合域内的苏氨酸自身磷酸化所抑制

Localization of activated Ca~(2+)/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation

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