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首页> 外文会议>Conference on Biomedical Applications of Micro-and Nanoengineering, Dec 16-18, 2002, Melbourne, Australia >Evaluation of the MOSFET type biosensor using glucose oxidase
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Evaluation of the MOSFET type biosensor using glucose oxidase

机译：使用葡萄糖氧化酶评估MOSFET型生物传感器

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A lot of researches and developments of medical device based on micromechatronics are performed. We develop the glucose sensor for using at HMS (Health Monitoring System) as one of the devices of those. In the development of a glucose sensor, it is necessary that the efficient hybridization between enzyme (glucose oxidase : GOD) as receptor and semiconductor as transducer. We devised the biosensor which used GOD immobilized gold plate as a gate electrode of the MOSFET. By utilizing this type, it becomes possible that the sensor part is easily miniaturized. When the glucose was detected using this sensor, there was a signal with concentration dependence. Therefore, it was confirmed that the prototype glucose sensor operated as a biosensor. From the above results, MOSFET type biosensor with gate electrode which immobilized GOD produced in this paper seems to be enough available as a glucose sensor. For miniaturization of the system, we examined the relationship between size of the working electrode and detection sensitivity. Consideration of the electrode area was not needed to detect the signal sensitively from the glucose sensor. And when we changed glass reference electrode to Au electrode, the enough sensitivity was obtained, too.
机译：进行了许多基于微机电一体化的医疗器械的研究与开发。我们开发了用于HMS（健康监测系统）的葡萄糖传感器，作为其中的一种设备。在葡萄糖传感器的开发中，有必要在作为受体的酶（葡萄糖氧化酶：GOD）与作为传感器的半导体之间进行有效的杂交。我们设计了一种生物传感器，该传感器使用固定有GOD的金板作为MOSFET的栅电极。通过利用这种类型，可以容易地使传感器部分小型化。当使用该传感器检测到葡萄糖时，会出现一个浓度依赖性的信号。因此，证实了原型葡萄糖传感器用作生物传感器。根据以上结果，本文中制备的固定有GOD的带有栅电极的MOSFET型生物传感器似乎足以用作葡萄糖传感器。为了使系统小型化，我们检查了工作电极尺寸与检测灵敏度之间的关系。无需考虑电极面积即可灵敏地检测来自葡萄糖传感器的信号。而且，当我们将玻璃参比电极改为金电极时，也获得了足够的灵敏度。

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