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首页> 外文会议>Conference on Biomedical Applications of Micro-and Nanoengineering, Dec 16-18, 2002, Melbourne, Australia >Biomedical applications of stereoregular poly(vinyl alcohol) micro- and nanoparticles
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Biomedical applications of stereoregular poly(vinyl alcohol) micro- and nanoparticles

机译：立体有规聚乙烯醇微颗粒和纳米颗粒的生物医学应用

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Syndiotactic poly(vinyl alcohol) (PVA)/poly(vinyl pivalate/vinyl acetate) (P(VPi/VAc)) and atactic PVA/PVAc micro- and nanoparticles with skin/core structure have been prepared by heterogeneous saponification of P(VPi/VAc) and PVAc micro- and nanoparticles. Especially, to prepare P(VPi/VAc) and PVAc microparticles having various particle sizes and uniform particle size distribution, vinyl pivalate (VPi)/vinyl acetate (VAc) and VAc were suspension-polymerized using a low-temperature initiator, 2,2'-azobis(2,4-dimethylvaleronitrile). P(VPi/VAc) particles are promising precursor of stereoregular PVA embolic materials which can be introduced through catheters in the management of gastrointestinal bleeders, arteriovenous malformations, hemangiomas, and traumatic rupture of blood vessels. Monodisperse and/or nearly monodisperse P(VPi/VAc) and PVAc microparticles with various particle diameters were obtained by controlling suspension polymerization conditions. Monodisperse P(VPi/VAc) and PVAc microparticles having various particle sizes were partially saponified in the heterogeneous system. PVA/P(VPi/VAc) and PVA/PVAc microparticles having various tacticity and degree of saponification were produced by controlling various polymerization and saponification conditions. The coating of stereoregular PVA micro- and nanoparticles for drug release experiments was conducted with the strepo-avidin-alkaline phosphatase conjugate in variable conditions of pH value, coating buffer, and reaction temperature. Protein-coated syndiotactic PVA micro-and nanoparticles, which does not crosslinking, were more superior to controllability of drug release, durability, and dimensional stability to water and blood than atactic one.
机译：通过对P（VPi）进行异质皂化制备了间同立构的聚乙烯醇（PVA）/聚新戊酸乙烯酯/乙酸乙烯酯（P（VPi / VAc））和无规立构的PVA / PVAc以及具有皮肤/核心结构的纳米颗粒/ VAc）和PVAc微米颗粒和纳米颗粒。尤其是，为了制备具有各种粒径和均匀粒径分布的P（VPi / VAc）和PVAc微粒，使用低温引发剂2,2使新戊酸酯（VPi）/乙酸乙烯酯（VAc）和VAc悬浮聚合。 '-偶氮二（2,4-二甲基戊腈）。 P（VPi / VAc）颗粒是有希望的立体规则性PVA栓塞材料的前体，可通过导管将其引入胃肠道出血，动静脉畸形，血管瘤和创伤性血管破裂的处理。通过控制悬浮聚合条件，获得具有各种粒径的单分散和/或几乎单分散的P（VPi / VAc）和PVAc微粒。具有各种粒径的单分散P（VPi / VAc）和PVAc微粒在异质体系中被部分皂化。通过控制各种聚合和皂化条件，制备了具有各种立构规整度和皂化度的PVA / P（VPi / VAc）和PVA / PVAc微粒。在不同的pH值，包被缓冲液和反应温度条件下，使用strepo-抗生物素蛋白-碱性磷酸酶偶联物进行立体定向PVA微粒和纳米颗粒的药物释放实验。蛋白质涂层的间规PVA微粒和纳米微粒不交联，比无规可控的药物释放性，持久性以及对水和血液的尺寸稳定性更好。

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