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首页> 外文会议>Conference on Biomedical Applications of Micro-and Nanoengineering, Dec 16-18, 2002, Melbourne, Australia >MICROENGINEERING OF ARTIFICIAL CAPILLARIES
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MICROENGINEERING OF ARTIFICIAL CAPILLARIES

机译：人造毛细血管的微工程

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摘要

Biocompatibility and functionality of implanted inorganic medical devices is limited by the local reaction of the organism, with a recently recognized contribution of nearby microvasculature. We explored the possibility to microengineer pre-embedded microvascular networks in the surface of inorganic devices. The implants would thus function as carriers of pre-assembled microvessels, ready to expand, and contribute to local angiogenesis. Based on our own studies on the role played by local microtopography in angiogenesis (the 'tunneling' concept), we have shown the feasibility of endothelial cells cultivation in grooves created on the surface of the materials to be implanted, either polymeric or silicon. In order to develop this new technology, we devised an in situ approach to the study of the cellular behavior on micropatterned surfaces, by use of Laser Scanning Cytometry (LSC). In this report I will present our results regarding the LSC analysis of endothelial cells cultivated in grooves made on the surface of silicon wafers, and the consequences of this treatment on endothelial physiology. When comparing the growth of endothelial cells on line patterned and non-patterned areas, in terms of several morphological parameters of cell nuclei, our data support the conclusion that lateral confinement of endothelial cells induces a quiescent state, possibly by inhibiting their ability to proliferate.
机译：植入的无机医疗器械的生物相容性和功能受到生物体的局部反应的限制，最近发现的附近微脉管系统对此做出了贡献。我们探索了在无机设备表面进行微工程预嵌入微血管网络的可能性。因此，植入物将充当预组装的微血管的载体，准备进行扩张，并有助于局部血管生成。基于我们自己对局部微观形貌在血管生成中的作用的研究（“隧道”概念），我们显示了在要植入的材料（聚合物或硅）表面上形成的凹槽中培养内皮细胞的可行性。为了开发这项新技术，我们设计了一种通过使用激光扫描细胞仪（LSC）研究微图案化表面上细胞行为的原位方法。在本报告中，我将介绍有关在硅片表面上制作的凹槽中培养的内皮细胞的LSC分析的结果，以及该处理对内皮生理的影响。当比较带图案的和非图案区域上的内皮细胞的生长时，就细胞核的几个形态学参数而言，我们的数据支持以下结论：内皮细胞的侧向局限性可能是通过抑制其增殖能力而引起的。

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